5860-48-0

Usage

Uses

Used in Organic Chemistry:
Oxopyrroline serves as a key intermediate in the synthesis of other important organic compounds, contributing to the development of a wide range of chemical products.
Used in Pharmaceutical Development:
Due to its versatile reactivity and unique structure, oxopyrroline is used as a building block in the creation of pharmaceuticals and other bioactive molecules, aiding in the advancement of new treatments and therapies.
Used in Chemical and Biological Applications:
Oxopyrroline's valuable properties make it an essential component in various chemical and biological applications, enhancing research and innovation in these fields.

Upstream product

• 29212-57-5 3-hydroxy-1H-pyrrole 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 29212-57-5 3-hydroxy-1H-pyrrole 

Relevant academic research and scientific papers

Polypyrrolinone based inhibitors of matrix metalloproteases

A compound of the formula wherein R1, R2, R3, R4, R5, R6 are as defined herein, useful for the inhibition of inhibition of matrix metalloproteases (MMPs)and for treating conditions mediated by elevated levels of MMPs such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, gingivitis, solid tumor growth and tumor invasion by secondary metastasis, corneal ulceration, dermal ulceration, epidermolysis bullosa, neural degeneration, multiple sclerosis and surgical wound healing.

New solution and solid phase synthesis of pyrrolinones and polypyrrolinones

The invention provides a new process for the preparation of polypyrrolinones (I) of various sizes which have found to be useful peptidomimetics. One aspect of the invention is a new process utilizing α-amino-α-substituted-valerolactones as synthons. A second aspect of the invention is a process for the synthesis of polypyrrolinones using solid-phase techniques. 1

Black-pigmented structured high molecular weight material

This invention relates to a black-pigmented high molecular weight organic material which is structured from a radiation-sensitive precursor by irradiation, the pigmentation of which material consists of coloured organic pigments, at least one of which is in latent form before irradiation. This material is preferably used as a thin layer which is built up in the form of patterns on a transparent substrate and which can be used, for example, as black matrix for optical colour filters. This invention also relates to a process for the preparation of this material as well as to novel soluble derivatives of yellow disazo condensation pigments which can be used in this process.

Tautomerism of the Monohydroxy Derivatives of Five-Membered O, N, and S Heterocycles

The O-deuterated enolic tautomers 3-deuteroxybenzofuran, 3-deuteroxybenzothiophene, 3-deuteroxyindole, 3-deuteroxy-1-methylindole, 3-deuteroxyfuran, 3-deuteroxythiophene, 2-deuteroxybenzothiophene, and 2-deuteroxythiophene have been generated in solution in mixtures of CD3COCD3, CD3CN, or CD3SOCD3 with D2O by hydrolysis of their trimethylsilyl derivatives in the presence of DCl (1E-3 - 1E-4 M) and characterized by 1H NMR spectroscopy.Solutions of 3-hydroxypyrrole and of 3-hydroxy-1-methylpyrrole were obtained by methanolysis of their trimethylsilyl derivatives,evaporation of the methanol, and immediate dissolution in DMSO-d6.The carbocyclic analogues of the bicyclic heterocyclic enols 3-deuteroxyindene and 2-deuteroxyindene were also generated in solution.Attempts to prepare solutions of 2-deuteroxyfuran, 2-deuteroxypyrrole, and 2-deuteroxy-1-methylpyrrole were unsuccessful.The kinetics of ketonization of the OH forms of these enols have been investigated in water or aqueous acetonitrile solution.The equilibrium constants for the keto-enol tautomerism were also determined either by direct measurement when sufficient enol was present at equilibrium or as the ratio of the rate constant for enolization of the keto form to that for ketonization of the enol form, the former being determined by the iodine-trapping technique.The effect of solvent on the equilibrium constants was also studied.Sufficient data were available for the equilibrium between 3-hydroxyindole and 3-ketoindole for them to be analyzed by the four-parameter equation of Mills and Beak to yield an a value of 2.4 and a b value of -3.0.The pKas of the bicyclic enols were measured. 3-Hydroxybenzofuran and3-hydroxybenzothiophene are stronger acids than 3-hydroxyindole and 3-hydroxy-1-methylindole.The ketonization reactions are general acid and general base catalyzed and their mechanisms are discussed.

Phenyl substituted aminodicarboxylate esters

The invention relates to pyrrolinones of formula (1) STR1 wherein R1 is an alkyl group containing at least 2 carbon atoms, an aralkyl group, an isocyclic or heterocyclic aromatic radical and R is an alkyl or aryl group. The invention also relates to aminodicarboxylates of formula (2) STR2 wherein R1 is as defined in claim 1 and R and R' are the same or different and are alkyl or aryl. The aminodicarboxylates of formula (2) are prepared by condensing a disuccinate of the formula with a nitrile of the formula R1 CN, in the presence of a strong base and zinc chloride. The pyrrolinones of formula (1) are obtained by reacting the aminodicarboxylates of formula (2) in the presence of a strong base in an organic solvent. The compounds of formulae (1) and (2) are valuable intermediates for pigments.

THE TAUTOMERISM OF HYDROXY DERIVATIVES OF FIVE-MEMBERED OXYGEN, NIRTOGEN, AND SULFUR HETEROCYCLES

The unstable enolic tautomers 3-hydroxyfuran, 2- and 3-hydroxy-thiophene, 3-hydroxy-pyrrole, 3-hydroxy-1-methyl-pyrrole and their benzo-derivatives have been generated in solution and the rate and equilibrium constants for their ketoization determined.