5860-52-6Relevant academic research and scientific papers
Reactions of substituted 2,3-dihydro-1H-indol-3-ones and pyrrolo[2,3-b]pyridin-3-ones with Wittig and Horner-Emmons reagents: Synthesis of 7-azatryptamine
Mérour, Jean-Yves,Gadonneix, Philippe,Malapel-Andrieu, Béatrice,Desarbre, Eric
, p. 1995 - 2002 (2001)
The reactivity of indolinone 1 towards Wittig and Horner-Emmons reactions was reported; the influence of the nature of substituent on the nitrogen atom was examined. 7-Azaindolinone 2 reacted with diethyl cyanomethanephosphonate for giving the corresponding (7-azaindol-3-yl)acetonitrile or more unexpectedly, a C-2 alkylated product; this behavior has been extended to another nucleophilic reagent. Finally the synthesis of 7-azatryptamine was reported.
