58607-04-8Relevant academic research and scientific papers
Catalytic Enantioselective α-Ketol Rearrangement
Wu, Hua,Andres, Rémi,Wang, Qian,Zhu, Jieping
supporting information, p. 499 - 503 (2018/12/13)
A highly enantioselective α-ketol rearrangement has been developed. In the presence of a chiral Cu-bisoxazoline complex, achiral β-hydroxy-α-dicarbonyls were isomerized to chiral α-hydroxy-β-dicarbonyls and their bicyclic derivatives in excellent yields and enantioselectivities. Enantioenriched 2-acyl-2-hydroxy cyclohexan-1-ones, dihydroxyhexahydrobenzofuranones, and dihydroxyhexahydro-cycloheptafuranones, with up to three stereocenters, were readily prepared from achiral starting materials in one operation. The reaction is applicable to the desymmetrization of meso substrates and kinetic resolution of racemic alcohols.
Applications of Phase Transfer Catalysis, 24. - Note on the Acceleration of Reactions between Alkynes and Carbonyl Compounds
Dehmlow, Eckehard V.,Shamout, Abdul Rahman
, p. 1750 - 1752 (2007/10/02)
Reactions between the title compounds in toluene/15percent aqueous sodium hydroxide are accelerated by the presence of N(C4H9)Br.
