58621-54-8

Basic information

• Product Name: CHEMBRDG-BB 3018393
• Synonyms: CHEMBRDG-BB 3018393;1-[3-(Allyloxy)phenyl]ethanone;1-[3-(allyloxy)phenyl]ethanone(SALTDATA: FREE);1-(3-prop-2-enoxyphenyl)ethanone;IVK/1415737;NCIOpen2_001225;NSC86587
• CAS NO: 58621-54-8
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 58621-54-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 270.1°Cat760mmHg
• Flash Point: 113°C
• Appearance: /
• Density: 1.018g/cm³
• Vapor Pressure: 0.00696mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: CHEMBRDG-BB 3018393(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 3018393(58621-54-8)
• EPA Substance Registry System: CHEMBRDG-BB 3018393(58621-54-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 58621-54-8(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 3018393, also known as N-(2-chloro-4-fluorophenyl)-2-((pyridin-2-ylmethyl)amino)benzamide, is a chemical compound with potential biological activity. It has been identified as a potential antagonist of the orexin 1 receptor, which is involved in the regulation of wakefulness and sleep. The compound is under investigation for its potential therapeutic applications in the treatment of sleep disorders and other conditions related to orexin receptor function. Its precise mechanism of action and potential side effects are still being studied, but its structure and activity make it a promising candidate for further research and drug development.

InChI:InChI=1/C11H12O2/c1-3-7-13-11-6-4-5-10(8-11)9(2)12/h3-6,8H,1,7H2,2H3

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 106-95-6 allyl bromide 
• 79250-49-0 1-(3-(allyloxy)phenyl)ethan-1-ol 

Downstream Products

• 79250-49-0 1-(3-(allyloxy)phenyl)ethan-1-ol 
• 865760-02-7 4'-allyl-3'-(2''-chloroethoxy)acetophenone 
• 865760-01-6 2'-allyl-3'-(2''-chloroethoxy)acetophenone 
• 865760-13-0 1-(benzofuran-6-yl)ethan-1-one 
• 95333-15-6 4-acetylbenzofuran 
• 58621-38-8 4'-allyl-3'-hydroxyacetophenone 
• 121-71-1 3-Hydroxyacetophenone 
• 58621-37-7 2'-allyl-3'-hydroxyacetophenone 

Relevant articles and documents

Nickel-catalyzed deallylation of aryl allyl ethers with hydrosilanes

An efficient and mild catalytic deallylation method of aryl allyl ethers is developed, with commercially available Ni(COD)2 as catalyst precursor, simple substituted bipyridine as ligand and air-stable hydrosilanes. The process is compatible with a variety of functional groups and the desired phenol products can be obtained with excellent yields and selectivity. Besides, by detection or isolation of key intermediates, mechanism studies confirm that the deallylation undergoes η3-allylnickel intermediate pathway.

Synthesis of Polysubstituted 3-Methylisoquinolines through the 6π-Electron Cyclization/Elimination of 1-Azatrienes derived from 1,1-Dimethylhydrazine

A convenient one pot microwave-assisted 6π-electron cyclization/aromatization approach toward 3-methylisoquinolines is reported. The starting 1-azatriene derivatives were prepared in situ by reaction of 2-propenylbenzaldehydes with 1,1-dimethylhydrazine, which exhibited superior performance when compared with other hydrazine derivatives. Minor amounts of the related 3,4-dihydro isoquinolines were formed concomitantly with the isoquinolines, and a mechanism for their generation was proposed. The reaction conditions were optimized, and its scope and limitations were explored. In general, the transformation proceeded in moderate to good yields.

CARBINOL DERIVATIVES HAVING CYCLIC LINKER

[Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.