586373-19-5

Upstream product

• 108379-95-9 1-benzyl-4-benzyloxypyridin-2(1H)-one 
• 870854-92-5 1-benzyl-4-methoxypyridin-2(1H)-one 
• 52545-13-8 4-methoxypyridin-2(1H)-one 
• 1122-96-9 4-methoxypyridine N-oxide 

Downstream Products

• 1046143-69-4 4-(3-bromopropoxy)-1-(2-chlorobenzyl)-2(1H)-pyridone 
• 586373-28-6 1-benzyl-3-bromo-2-oxo-1,2-dihydropyridin-4-yl methyl(phenyl)carbamate 
• 586373-20-8 1-benzyl-3-bromo-2-oxo-1,2-dihydropyridin-4-yl trifluoromethanesulfonate 
• 586373-21-9 1-benzyl-3-bromo-4-(phenylethynyl)pyridin-2(1H)-one 
• 586373-17-3 1-benzyl-3-bromo-4-(2-phenylethyl)pyridin-2(1H)-one 
• 586373-18-4 1-benzyl-3-bromo-4-hydroxypyridine-2(1H)-one 
• 586373-29-7 1-benzyl-2-oxo-1,2-dihydropyridin-4-yl methyl(phenyl)carbamate 

Relevant academic research and scientific papers

INHIBITORS OF BRUTON'S TYROSINE KINASE

Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.