586375-30-6Relevant academic research and scientific papers
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases
Vincetti, Paolo,Caporuscio, Fabiana,Kaptein, Suzanne,Gioiello, Antimo,Mancino, Valentina,Suzuki, Youichi,Yamamoto, Naoki,Crespan, Emmanuele,Lossani, Andrea,Maga, Giovanni,Rastelli, Giulio,Castagnolo, Daniele,Neyts, Johan,Leyssen, Pieter,Costantino, Gabriele,Radi, Marco
, p. 4964 - 4975 (2015/07/02)
This study describes the discovery of novel dengue virus inhibitors targeting both a crucial viral protein-protein interaction and an essential host cell factor as a strategy to reduce the emergence of drug resistance. Starting from known c-Src inhibitors
SUBSTITUTED PYRIDINONES
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Page/Page column 355-356, (2008/06/13)
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
