586396-98-7

Upstream product

• 586397-31-1 methyl (2S,3S)-N'-(2-(3-(3,5-bis(trifluoromethyl)benzyloxymethyl)-4-methyl-5-oxo-2-phenylpiperazin-1-yl)-1-iminoethyl)hydrazinocarboxylate 

Relevant academic research and scientific papers

Novel 2-phenylpiperazine derivatives

Excellent tachykinin receptor antagonistic activity is provided by 2-phenylpiperazine derivatives. The piperazine derivatives exhibit a strong inhibitory action against a tachykinin-induced increase of vascular permeability in in vivo tests. Moreover, the derivatives show a preferred transfer into blood, a long half-life in blood in pharmacokinetic tests of oral administration to rats or guinea pigs, and are very stable in blood plasma of various animals. Consequently, a piperazine derivative of the present invention is very useful as a tachykinin antagonist.

Novel 2-phenylpiperazine derivatives

The present invention is to offer a useful novel compound as a tachykinin antagonist.ψThis invention is a novel 2-phenylpiperazine derivative having an excellent tachykinin antagonistic action.ψA piperazine derivative of the present invention has an excellent tachykinin receptor antagonistic activity and exhibits a strong inhibitory action against tachykinin-induced increase of vascular permeability in vivo tests. Moreover, it shows a preferred transfer into blood and a long half-life in blood in pharmacokinetic tests of oral administration to rats or guinea pigs, and is very stable in blood plasma of various animals. Consequently, a piperazine derivative of the present invention is very useful as a novel tachykinin antagonist.