586412-63-7Relevant academic research and scientific papers
Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II
Ward, Simon E.,Eddershaw, Peter,Flynn, Sean T.,Gordon, Laurie,Lovell, Peter J.,Moore, Susan H.,Scott, Claire M.,Smith, Paul W.,Thewlis, Kevin M.,Wyman, Paul A.
scheme or table, p. 428 - 432 (2011/03/18)
A series of 5-(piperidinylethyloxy)quinoline 5-HT1 receptor ligands have been studied by elaboration of the series of dual 5-HT1-SSRIs reported previously. These new compounds display a different in vitro pharmacological profile with potent affinity across the 5-HT1A, 5-HT1B and 5-HT1D receptors and selectivity against the serotonin transporter. Furthermore, they have improved pharmacokinetic profiles and CNS penetration.
