586415-12-5Relevant articles and documents
Total synthesis and anti-viral activities of an extract of radix isatidis
He, Li-Wei,Chen, Yu-Qing,Yang, Jing-Yan,Wang, Tian-Lin,Li, Wei,Liu, Hua-Qing
, p. 20906 - 20912 (2014)
Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble
Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [3H]Glyburide binding to rat brain synaptosomes
Hill, Ronald A.,Rudra, Sonali,Peng, Bo,Roane, David S.,Bounds, Jeffrey K.,Zhang, Yang,Adloo, Ahmad,Lu, Tiansheng
, p. 2099 - 2113 (2007/10/03)
We are seeking to discover potent CNS-active sulfonylureas with structural features that allow for the formation of several types of prodrugs. We report herein the syntheses of compounds comprising an initial series of hydroxyl-substituted analogues of the potent ATP-sensitive potassium channel blockers glyburide (glibenclamide) and gliquidone. Somewhat unexpectedly, several of the compounds were found to be comparably potent to glyburide as inhibitors of specific [3H]glyburide binding in rat brain preparations.