58653-97-7Relevant articles and documents
Alkylglycidic Acids: Potential New Hypoglycemic Agents
Ho, Winston,Tutwiler, Gene F.,Cottrell, Sandra C.,Morgans, Dave J.,Tarhan, Okan,Mohrbacher, Richard J.
, p. 2184 - 2190 (1986)
A series of alkylglycidic acid analogues and derivatives were synthesized and tested for their ability to inhibit long-chain fatty acid oxidation in vitro and to lower blood sugar in rats.The extent of inhibition of carnitine acyl transferase, the enzyme
Regioselective Carbonylation of 2,2-Disubstituted Epoxides: An Alternative Route to Ketone-Based Aldol Products
Hubbell, Aran K.,Lapointe, Anne M.,Lamb, Jessica R.,Coates, Geoffrey W.
supporting information, p. 2474 - 2480 (2019/02/14)
We report the regioselective carbonylation of 2,2-disubstituted epoxides to β,β-disubstituted β-lactones. Mechanistic studies revealed epoxide ring-opening as the turnover limiting step, an insight that facilitated the development of improved reaction conditions using weakly donating, ethereal solvents. A wide range of epoxides can be carbonylated to β-lactones, which are subsequently ring-opened to produce ketone-based aldol adducts, providing an alternative to the Mukaiyama aldol reaction. Enantiopure epoxides were demonstrated to undergo the carbonylation/ring-opening process with retention of stereochemistry to form enantiopure β-hydroxy esters.
Epoxidation and oxidation reactions using divinyl benzene crosslinked polystyrene supported t-butyl hydroperoxide
Sheela,Sreekumar
, p. 943 - 950 (2007/10/03)
Divinyl benzene (DVB) crosslinked polystyrene supported t-butyl hydroperoxide resin has been prepared and employed in the epoxidation of olefins and oxidation of alcohols. The reagent is found to be efficient as the low molecular weight t-butyl hydroperoxide. Presence of catalyst enhanced the reaction efficiency remarkably. Influence of various reaction parameters such as solvent, temperature and molar excess of the reagent on the reactivity of the polymeric reagent is also being investigated.
