58666-10-7

Usage

Chemical Class

The compound is a diethyl ester of malonic acid, which is a common building block in organic chemistry.

Substitution

The compound contains a chlorine-substituted phenyl group, which can make it useful for reactions involving nucleophilic substitution.

Functional Group

The compound contains an amino-methylene group, which can make it useful for condensation reactions.

Potential Applications

The compound has potential applications in the field of medicine and organic synthesis.

Starting Material

The compound may be used as a starting material for the synthesis of various pharmaceuticals or organic molecules with specific properties.

Medicinal Uses

The compound's potential medicinal uses could include serving as a precursor to drugs for various diseases or as a research tool in the development of new drug candidates.

Unique Structure and Reactivity

The compound's unique structure and reactivity may make it useful in the development of new materials or as a reagent in organic synthesis.

Upstream product

• 87-60-5 3-chloro-2-methylbenzenamine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 5350-94-7 7-chloro-8-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 405923-50-4 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo

Quinolone-3-carboxamides 11 bearing at position 5, 6, 7, or 8 diverse substituents such as halides, alkyl, aryl, alkoxy, and aryloxy groups differing in their steric/electronic properties, were prepared. The new compounds were tested in vitro for CB1 and

Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2

Due to the emerging role of protein kinase CK2 as a molecule that participates not only in the development of some cancers but also in viral infections and inflammatory failures, small organic inhibitors of CK2, besides application in scientific research, may have therapeutic significance. In this paper, we present a new class of CK2 inhibitors-3-carboxy-4(1H)-quinolones. This class of inhibitors has been selected via receptor-based virtual screening of the Otava compound library. It was revealed that the most active compounds, 5,6,8-trichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (7) (IC 50 = 0.3 μM) and 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid (9) (IC50 = 1 μM), are ATP competitive (Ki values are 0.06 and 0.28 μM, respectively). Evaluation of the inhibitors on seven protein kinases shows considerable selectivity toward CK2. According to theoretical calculations and experimental data, a structural model describing the key features of 3-carboxy-4(1H)-quinolones responsible for tight binding to CK2 active site has been developed.