58670-26-1 Usage
Uses
Used in Pharmaceutical Industry:
1-(5-chloro-2-methylphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione is used as a potential therapeutic agent for its reported anticancer and anti-inflammatory properties. Its ability to target cancer cells and reduce inflammation makes it a subject of interest for the development of new drugs to treat various diseases.
Used in Drug Development Research:
In the field of drug development, 1-(5-chloro-2-methylphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione serves as a valuable compound for further study. Its unique structure and potential biological activities provide a foundation for exploring new therapeutic approaches and understanding the underlying mechanisms of action.
Used in Medicinal Chemistry:
1-(5-chloro-2-methylphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione is utilized as a key component in the synthesis of novel compounds with potential medicinal applications. Its structural features and biological activities make it an attractive candidate for the design and development of new drugs targeting various diseases, including cancer and inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 58670-26-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,6,7 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 58670-26:
(7*5)+(6*8)+(5*6)+(4*7)+(3*0)+(2*2)+(1*6)=151
151 % 10 = 1
So 58670-26-1 is a valid CAS Registry Number.
58670-26-1Relevant academic research and scientific papers
The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation
Li, Shanshan,Song, Gao,Wang, Liang-Liang,Weng, Zhiying,Xu, Guowei,Yang, Weimin,Yang, Yanming,Yang, Yaqing,Zhang, Jiajun,Zuo, Zhili
, (2020/02/27)
Adenylate cyclases (ACs), play a critical role in the conversion of adenosine triphosphate (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10 μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chemical probe to study the physiological function of AC2.
