586952-09-2Relevant academic research and scientific papers
Ru(II)-Pheox-catalyzed asymmetric intramolecular cyclopropanation of electron-deficient olefins
Nakagawa, Yoko,Chanthamath, Soda,Shibatomi, Kazutaka,Iwasa, Seiji
supporting information, p. 2792 - 2795 (2015/06/16)
The first highly enantioselective intramolecular cyclopropanation of electron-deficient olefins, in the presence of Ru(II) - Pheox catalyst, is reported. The corresponding cyclopropane-fused γ-lactones were obtained in high yields (up to 99%) with excelle
Organocatalytic asymmetric oxy-Michael addition to a γ-hydroxy- α,β-unsaturated thioester via hemiacetal intermediates
Okamura, Takaaki,Asano, Keisuke,Matsubara, Seijiro
supporting information; experimental part, p. 5076 - 5078 (2012/07/02)
We report an asymmetric oxy-Michael addition to a γ-hydroxy-α, β-unsaturated thioester via hemiacetal intermediates in the presence of Cinchona-alkaloid-thiourea-based bifunctional organocatalysts. This method provides a novel enantioselective route to β-hydroxy carboxyl compounds, which in turn can be used to synthesize valuable chiral building blocks.
Stereoselective preparation of 3-alkanoylprop-2-en-1-ol derivatives
Sada, Mutsumi,Ueno, Shizue,Asano, Keisuke,Nomura, Kenichi,Matsubara, Seijiro
body text, p. 724 - 726 (2009/07/25)
3-Alkanoylprop-2-en-1-ol derivatives were prepared stereoselectively by ring-opening reaction of β,γ-epoxyketone with amines. Georg Thieme Verlag Stuttgart.
Homochiral oxazolidin-2-ones and imidazolidin-2-ones by tandem nucleophilic addition-conjugate addition
Ciclosi, Marco,Fava, Cristiana,Galeazzi, Roberta,Orena, Mario,Gonzalez-Rosende, Maria Eugenia,Sepulveda-Arques, Jose
, p. 1937 - 1943 (2007/10/03)
Treatment of both primary alcohols 1a,b and secondary amines 1c,d, tethered to a Michael acceptor with (R)-phenylethyl isocyanate in the presence of DBU gave in good yield and high stereoselection diastereomeric mixtures of oxazolidin-2-ones 2a,b and 3a,b
Stereoselective synthesis of trans-4,5-disubstituted oxazolidin-2-ones by intramolecular conjugate addition of N-p-toluenesulfonyl carbamates
Ciclosi, Marco,Fava, Cristiana,Galeazzi, Roberta,Orena, Mario,Sepúlveda-Arques, José,González-Rosende, Maria Eugenia
, p. 1173 - 1183 (2007/10/03)
p-Toluenesulfonyl carbamates (2a-d) were prepared starting from allylic alcohols (3), in which the double bond is conjugated with an electron withdrawing group. In the presence of a catalytic amount of DBU, an intramolecular cyclisation occurred, leading
