586953-05-1Relevant academic research and scientific papers
The reaction of 4-amino-2-oxazolines with isocyanates and isothiocyanates. Synthesis and X-ray structures of polysubstituted 2-imidazolidinones, 1,3-oxazolidines and 1,3-thiazolidines
Guirado, Antonio,Andreu, Raquel,Martiz, Bruno,Bautista, Delia,Ramírez de Arellano, Carmen,Jones, Peter G.
, p. 6172 - 6181 (2007/10/03)
Reactions of 4-alkylamino-2-phenyl-2-oxazolines 1 with isocyanates and isothiocyanates provide unprecedented efficient and regioselective heterocycle-heterocycle transformations. Compounds 1 reacted rapidly with tosyl isocyanate yielding directly 3-alkyl-
Direct conversion of 4-amino-2-phenyl-2-oxazolines into either 2-arylimino-1,3-oxazolidine or 2-arylimino-1,3-thiazolidine hydrochlorides
Guirado, Antonio,Andreu, Raquel,Gálvez, Jesús
, p. 3809 - 3812 (2007/10/03)
A novel heterocycle-heterocycle inter-conversion is reported. It enables direct and efficient syntheses of either polysubstituted 2-arylimino-1,3-oxazolidine or 2-arylimino-1,3-thiazolidine hydrochlorides by a one-pot treatment of 4-amino-2-phenyl-2-oxazolines with arylisocyanates or arylisothiocyanates, respectively, followed by addition of hydrochloric acid.
