586958-75-0

Upstream product

• 362621-38-3 (R)-(4-Hydroxy-cyclohexyl)-(4'-methoxy-biphenyl-4-sulfonylamino)-acetic acid 
• 369656-86-0 Methyl (R)-N-{[4'-Methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-(4-hydroxy-cyclohex-1-yl)-acetate 
• 209460-85-5 (2R)-2-Amino-2-(4-hydroxycyclohexyl)acetic Acid 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 100-46-9 benzylamine 
• 369598-85-6 Methyl (R)-N-{[4'-Methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-(4-oxocyclohex-1-yl)-acetate 

Relevant academic research and scientific papers

Carbocyclic side chain containing metalloprotease inhibitors

The compounds have a structure according to the following Formula (I): are effective in treating conditions characterized by excess activity of these enzymes.

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

A series of carboxylic acids was prepared based on cyclohexylglycine scaffolds and tested for potency as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for five enzymes within the MMP family, and a number of inhibitors such as compound 18 display low nanomolar potency for MMP-2 and MMP-13, while selectively sparing MMP-1 and MMP-7.