58697-25-9Relevant academic research and scientific papers
Strategy for the isolation, derivatization, chromatographic separation, and detection of carnitine and acylcarnitines
Minkler, Paul E.,Ingalls, Stephen T.,Hoppel, Charles L.
, p. 1448 - 1457 (2005)
A strategy for detection of carnitine and acylcarnitines is introduced. This versatile system has four components: (1) isolation by protein precipitation/desalting and cation-exchange solid-phase extraction, (2) derivatization of carnitine and acylcarniti
Solvent isotope effect on the hydroxide-ioncatalyzed hydration of ketenes in aqueous solution
Andraos,Chiang,Eustace,Kresge,Paine,Popik,Sung
, p. 459 - 462 (2007/10/03)
Five ketenes, phenyl(ethyl)ketene, phenyl(methylthio)ketene, diphenylketene, pentafluorophenylketene, and 1-naphthylketene, were generated flash photolytically and solvent isotope effects (H2O vs. D2O) on their hydroxide-ioncatalyzed hydration in aqueous solution were determined. The values obtained are all weakly reverse and closely similar (k(HO)/k(DO) = 0.76-0.97), as expected for these fast, hydroxide-ion-consuming reactions, known to proceed by nucleophilic attack of hydroxide on the ketene carbonyl group. The characteristic magnitude of these isotope effects should prove useful in identifying new examples of this reaction.
