586977-98-2Relevant academic research and scientific papers
Cyclization into perhydronaphthalenones using samarium diiodide
Sono, Masakazu,Onishi, Sachiko,Tori, Motoo
, p. 3385 - 3395 (2007/10/03)
Samarium(II) diiodide has been employed to promote the intramolecular cyclization reactions of aldehydes or ketones onto α,β-unsaturated ketones. The cyclization reactions described herein provide a general approach to the syntheses of perhydronaphthalenones with a cis-relationship between the OH at C-5 and the proton or methyl group at C-4a with good diastereoselectivity under mild reaction conditions.
