5870-29-1 Usage
Description
Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM, respectively). Formulations containing cyclopentolate have been used to induce pupil dilation and to prevent the eye from accommodating for near vision.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 5870-29-1 differently. You can refer to the following data:
1. Mydriatic;Cholinergic receptor antagonist
2. antiviral
3. A mydriatic
General Description
Cyclopentolatehydrochloride, 2-dimethylaminoethyl 1-hydroxy- -phenylcyclopentaneacetatehydrochloride (Cyclogyl), is a crystalline,white, odorless solid that is very soluble in water,easily soluble in alcohol, and only slightly soluble in ether.A 1% solution has a pH of 5.0 to 5.4.Cyclopentolate hydrochloride has one half of the antispasmodicactivity of atropine and is nonirritating when instilledrepeatedly into the eye. If not neutralized after the refractionstudies, its effect dissipates within 24 hours. Neutralizationwith a few drops of pilocarpine nitrate solution, 1% to 2%,often results in complete recovery in 6 hours. It is supplied asa ready-made ophthalmic solution in concentrations of either0.5% or 2%.
Clinical Use
Cyclopentolate Hydrochloride is used only for its effects on the eye, where it acts asa parasympatholytic. When placed in the eye, it quickly producescycloplegia and mydriasis. Its primary field of usefulnessis in refraction studies. Cyclopentolate hydrochloridecan be used, however, as a mydriatic in the management ofiritis, iridocyclitis, keratitis, and choroiditis. Although itdoes not seem to affect intraocular tension significantly, it isbest to be very cautious with patients with high intraocularpressure and with elderly patients with possible unrecognizedglaucomatous changes.
Check Digit Verification of cas no
The CAS Registry Mumber 5870-29-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,7 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5870-29:
(6*5)+(5*8)+(4*7)+(3*0)+(2*2)+(1*9)=111
111 % 10 = 1
So 5870-29-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H25NO3.ClH/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17;/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3;1H
5870-29-1Relevant articles and documents
Preparation method of cyclopentolate hydrochloride
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Paragraph 0014; 0041, (2017/05/04)
The invention relates to a preparation method of an M-type cholinoceptor blocker cyclopentolate hydrochloride. The preparation method comprises that phenylacetic acid as an initial raw material and cyclopentanone undergoes a reaction to produce 2-(1-hydroxycyclopentyl)-phenylacetic acid (as intermediate 3), the 2-(1-hydroxycyclopentyl)-phenylacetic acid undergoes a replacement reaction and the reaction product undergoes a salification reaction to produce cyclopentolate hydrochloride. The preparation method can be operated simply, is safe and controllable, has low labor protection demands and is suitable for industrial production.
