587023-38-9Relevant academic research and scientific papers
1,3-Rearrangement of ketene-N,O-acetals
Suzuki, Tatsuo,Inui, Masaharu,Hosokawa, Seijiro,Kobayashi, Susumu
, p. 3713 - 3716 (2007/10/03)
Ketene N,O-acetals were prepared stereoselectively and submitted to a Lewis acid-mediated 1,3-rearrangement to afford C-alkylated products. The reactions proceeded in a stereoselective manner to construct a chiral quaternary carbon in high selectivity. The stereochemistry of the quaternary center was found to be opposite to that obtained by an anionic direct dienolate alkylation.
