5874-17-9

Basic information

• Product Name: (2E)-3-[1-(4-acetylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-cyano-N-phenylprop-2-enamide
• CAS NO: 5874-17-9
• Molecular Formula: C₂₉H₄₄O₆
• Molecular Weight: 383.4424
• Mol File: 5874-17-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 636.9°C at 760 mmHg
• Flash Point: 339°C
• Density: 1.13g/cm³
• Vapor Pressure: 4E-16mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: (2E)-3-[1-(4-acetylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-cyano-N-phenylprop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-[1-(4-acetylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-cyano-N-phenylprop-2-enamide(5874-17-9)
• EPA Substance Registry System: (2E)-3-[1-(4-acetylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-cyano-N-phenylprop-2-enamide(5874-17-9)

Safety Data

• Hazardous Substances Data: 5874-17-9(Hazardous Substances Data)

Upstream product

• 1061-54-7 diosgenin acetate 
• 1061-54-7 diosgenin acetate 
• 512-04-9 diosgenin 
• 108-24-7 acetic anhydride 
• 56786-63-1 (25R)-3β,5-dihydroxy-5α-spirostan-6-one 
• 41336-85-0 3β-acetoxy-epoxy-22β-spirostane 

Downstream Products

• 56786-63-1 (25R)-3β,5-dihydroxy-5α-spirostan-6-one 
• 96575-25-6 3β-acetoxy-5,6-seco-5-oxo-22β-spirostan-6-oic acid 
• 325125-66-4 C₂₇H₄₀O₅ 

Relevant articles and documents

Synthesis of diosgenin derivatives by A and B ring modifications and low-valent titanium (Ti0)-catalysed McMurry coupling reactions and designing to create novel biological agents

Diosgenin is a steroidal sapogenin ((25R)-spirost-5-en-3β-ol) occurs abundantly in therapeutic herbs such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. It demonstrates a wide range of pharmacological activities and medicinal properties in a large of experimental and theoretical studies. It also constitutes an important class of compounds for new drug development. In the current study, diosgenin derivatives were synthesized and designed, aiming to discover new steroid-based biological agents. In this work, new diosgenin derivatives were synthesized through low-valent titanium (Ti0)-catalyzed McMurry coupling reaction and structural modifications to the A- and B- rings in the diosgenin. McMurry reaction gave the A-nor and B-nor derivatives in by the intramolecular reductive dimerization of carbonyl compounds in the presence of low-valent titanium agents, in moderate yields (46–47%). The modification reactions on the A and B rings of diosgenin were accomplished by using efficient reagents to give three different series, in moderate to high yields (55–97%). The structures of all novel derivatives were confirmed by FTIR, 1H NMR, 13C NMR, and HRMS methods.

A rapid and simple one-pot procedure for the synthesis of 3β-acetoxy-5α-hydroxy-6-oxo steroids

A fast one-pot procedure for the synthesis of 5α-hydroxy-6-oxo steroids is described. Epoxidation of 3β-hydoxy-Δ5 steroids followed by oxidative cleavage of the resulting epoxide with aqueous CrO3 lead to the desired compounds without affection of labile side chains. ARKAT USA, Inc.

Schmidt Reaction of 3β-Acetoxy-5α-hydroxy-22β-spirostan-6-one and Beckmann Rearrangement of Corresponding Ketoxime

3β-Acetoxy-5α-hydroxy-22β-spirostan-6-one (2), obtainable from diosgenin acetate, undergoes second order Schmidt reaction to form 3β-acetoxy-5-oxo-22β-spirostan-7-nitrile (3); the same nitrile is also obtained by the Beckmann rearrangement of the ketoxime