58758-45-5

Usage

InChI:InChI=1/C11H10O3/c1-3-7-14-11-9(8-12)5-4-6-10(11)13-2/h1,4-6,8H,7H2,2H3

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 106-96-7 propargyl bromide 

Downstream Products

• 154470-31-2 2-(3-methoxy-2-prop-2-ynyloxyphenyl)-4,5-dihydro-1,3-dithiole 
• 1092973-13-1 2,4-dimethyl-9-methoxy-4,12b-dihydro-1H,7H-chromeno[4',3'-4,5]pyrano[2,3-d]pyrimidine-1,3(2H)-dione 
• 1126527-63-6 8-methoxy-1-methyl-3-phenyl-3,11b-dihydro-6H-chromeno[4',3':4,5]pyrano[2,3-c]pyrazole 
• 1199943-16-2 4-methoxy-9-phenyl-9,13c-dihydro-6H-chromeno[4',3':4,5]thiopyrano[2,3-b]indole 
• 1334473-06-1 2-(2-(4-chlorophenyl)-2-oxoethyl)-7-methoxy-2-methylbenzofuran-3(2H)-one 
• 3533-45-7 2,2'?[hydrazinediylidenedimethanylylidene]bis(6?methoxyphenol) 
• 1350520-75-0 7-methoxy-2-(2-(3-methoxy-2-(prop-2-ynyloxy)phenyl)-2-oxoethyl)-2-methylbenzofuran-3(2H)-one 
• 1350520-72-7 C₂₂H₂₀O₆ 
• 1314890-08-8 C₁₁H₁₀Br₂O₄ 
• 1224713-05-6 4-[2-(8-methoxy-4-oxo-chroman-3-yl)-acetyl]-benzoic acid methyl ester 
• 1224713-01-2 8-methoxy-3-[2-(3-methoxy-phenyl)-2-oxo-ethyl]-chroman-4-one 
• 1224712-98-4 8-methoxy-3-(2-oxo-2-o-tolyl-ethyl)-chroman-4-one 
• 1224713-02-3 3-[2-(4-bromo-phenyl)-2-oxo-ethyl]-8-methoxy-chroman-4-one 
• 1224713-04-5 8-methoxy-3-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-chroman-4-one 

Relevant academic research and scientific papers

Exploring intermolecular contacts in multi-substituted benzaldehyde derivatives: X-ray, Hirshfeld surface and lattice energy analyses

Crystal structures of six benzaldehyde derivatives (1-6) have been determined and their supramolecular networks were established by an X-ray crystallographic study. The study has shown that the compounds are linked by various intermolecular interactions s

Synthesis and spectral study of a new family of 2,5-diaryltriazoles having restricted rotation of the 5-aryl substituent

Efficient synthesis of 2,5-diaryl substituted 4-azido-1,2,3-triazoles by the reaction of sodium azide with dichlorosubstituted diazadienes was demonstrated. The optical properties of the prepared azidotriazoles were studied to reveal a luminescence maximu

Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies

Carbonic anhydrases isoforms CA IX, and XII are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for especially colorectal cancers, because it is overexpressed in colorectal cancer and this overexpression

NHC-Stabilized Radicals in the Formal Hydroacylation Reaction of Alkynes

Mechanistic details of transformations catalyzed by N-heterocyclic carbenes (NHC) are currently of great interest, targeting questions on the active catalyst in operation and the structure and reactivity of key intermediates. These mechanistic studies are

Coumarin-1,2,3-triazole hybrid derivatives: Green synthesis and DFT calculations

A series of new 1,2,3-triazole-coumarin hybrid system are synthesized from the click reaction between 3-azido coumarin and different aromatic terminal alkyne derivatives in a green manner. All compounds are characterized by IR, NMR and UV–VIS spectroscopy

“On water” cascade synthesis of benzopyranopyrazoles and their macrocycles

Reported herein is an intramolecular 1,3-dipolar cycloaddition strategy for rapid entry into benzopyranopyrazoles (BPP) on water medium as “open flask chemistry” approach. The in situ generation of diazo functionality in two-step sequence from the appropr

Efficient one pot synthesis of chromenonaphthyridine derivatives by CuI/InCl3 catalyzed aza diels-alder reaction

A mild and efficient method for the synthesis of chromenonaphthyridine derivatives via domino reaction of aminopyridine and different O-propargylated salicylaldehydes using CuI/InCl3 as an efficient catalyst, refluxed in acetonitrile is reported. Mild rea

Copper-catalyzed intramolecular domino synthesis of 6H-chromeno[4,3-b]quinolines in green condition

A one-pot and efficient copper-catalyzed approach for synthesis of tetracyclic 6H-chromeno[4,3-b]quinolines through the intramolecular domino condensation-aza-Diels-Alder reaction of electron-rich anilines and Opropargylated salicylaldehydes under green conditions has been described.

Synthesis of Novel 7-methylene-6,7-dihyrobenzo[f]Benzo[4,5]Imidazo[1,2-d][1,4]Oxazepines via Base-mediated Regioselective Intramolecular Hydroamination

A versatile and transition metal-free approach for the synthesis of new 7-methylene-6,7-dihyrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepines were developed by an efficient 7-exo-dig regioselective hydroamination of 2-(2-(prop-2-yn-1-yloxy)phenyl)-1H-benzo[d]imidazole in the presence of potassium carbonate in DMF at 90°C.

Synthesis, DNA binding affinity and anticancer activity of novel 4: H -benzo [g] [1,2,3]triazolo[5,1- c] [1,4]oxazocines

A new class of tricyclic heterocycles 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines was synthesized through a Knoevenagel condensation/azide-alkyne cycloaddition reaction cascade in one-pot operation. These eight membered ring containing heterocycles exhibited moderately high anticancer activity against four cancer cell lines; human cervix cancer cell line (HeLa), human prostate cancer cell line (DU145), human breast cancer cell line (MCF-7) and human breast adenocarcinoma epithelial cell line (MDA-MB-231). Our results indicate that these compounds have a weak cytotoxic effect on normal human mammary epithelial cell line (MCF-10A). Cell cycle and apoptosis assay indicate that they inhibit the cell cycle at the G2/M phase and induce apoptosis. Through the RED100 assay, it is evident that they have potential to inhibit pBR 322 plasmid DNA cleavage by BamH1. UV-visible, fluorescence titration and viscosity studies suggested that these compounds possess DNA binding affinity.