58775-55-6Relevant academic research and scientific papers
Synthetic Strategy for Construction of Highly Congested Tetracyclic Core (6-5-7-4) of Harziane Diterpenoids
Tu, Qian,Wang, Zheyuan,Zhang, Zhongchao,Huang, Jun,Yang, Zhen
, p. 4088 - 4093 (2021)
The structurally intriguing tetracyclic core of complex harziane diterpenoid was constructed in 14 steps from commercially available 3-ethoxycyclohex-2-en-1-one. The key steps were a Mn/Cu-mediated oxidative 1,3-dicarbonyl radical cascade cyclization reac
Total synthesis of (±)-garsubellin A
Kuramochi, Akiyoshi,Usuda, Hiroyuki,Yamatsugu, Kenzo,Kanai, Motomu,Shibasaki, Masakatsu
, p. 14200 - 14201 (2007/10/03)
The first total synthesis of garsubellin A, a neurotrophic compound with potent choline acetyltransferase-inducing activity, is described. Keys for success were (1) stereoselective intermolecular aldol reaction at the C-4 position with acetaldehyde, (2) stereoelective Claisen rearrangement to introduce an allyl group to the most sterically crowded position at C-6, (3) ring-closing metathesis to construct the B-ring, and (4) Wacker-type oxidative C-ring formation. This synthetic route can be extended to an asymmetric synthesis of garsubellin A using the Koga catalytic enantioselective alkylation, which produced enantioenriched α-prenyl cyclohexenone with excellent enantioselectivity (95% ee). Copyright
Pyrazolopyridine cycloalkanones and process for their preparation
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, (2008/06/13)
Novel tetrahydropyrazolo-[3,4-b]quinolinones, cyclopenta[b]pyrazolo-[4,3-e]pyridinones and cyclohepta[b]-pyrazolo[4,3-e]pyridinones, useful as anxiolytics having reduced side effects, are disclosed, including methods of preparation, pharmaceutical compositions containing them and intermediates used in their preparation.
