58775-64-7

Upstream product

• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 10415-47-1 (methylthio)methyllithium 
• 75-18-3 dimethylsulfide 
• 23074-59-1 3-isobutoxycyclohex-2-en-1-one 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 80206-63-9 Acetic acid 3-iodomethyl-cyclohex-2-enyl ester 
• 80206-64-0 5-(3-Acetoxy-cyclohex-1-enyl)-3-oxo-pentanoic acid methyl ester 
• 1204114-64-6 N-((3-hydroxycyclohex-1-en-1-yl)methyl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 
• 1204114-68-0 C₂₇H₂₇NO₃S 
• 1204114-72-6 C₃₁H₂₉NO₃S 
• 1204114-74-8 C₂₄H₂₇NO₃S 
• 1204114-78-2 C₂₄H₂₇NO₄S 
• 1354575-42-0 C₂₆H₂₉NO₅S 
• 1354575-43-1 C₂₃H₂₄N₂O₅S 
• 1354575-44-2 C₁₈H₂₃NO₃S 
• 1354575-45-3 C₁₇H₂₁NO₃S 

Relevant academic research and scientific papers

Synthesis of Spirolactams and Fused Bicyclic Lactams via Acid-Promoted Cyclolactamization of (Ethynyl(tosyl)amino)methyl-Tethered Cyclohex-2-enols

A simple synthetic method to construct the spirolactam framework from TfOH-catalyzed spirolactamization of cyclohex-2-enols bearing a tethered (arylethynyl(tosyl)amino)methyl moiety is described. The reaction proceeded through a keteniminium-allylic carbocation intermediate. Hydration of the keteniminium ion, followed by attack of the resulting enolate onto the tethered allylic carbocation, provided the spirolactam ring skeleton. This strategy could also be employed in the synthesis of fused bicyclic lactams from BF3·OEt2-assisted cyclolactamization of TBS-protected 2-(ethynyl(tosyl)amino)methylcyclohex-2-enols.

Synthesis of 2-azaspiro[4.6]undec-7-enes from N -tosyl- N -(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols

The FeCl3-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expansion/cyclization/chlorination of N-tosyl-N-(3- arylpropargyl)-tethered 6-methylbicyclo[4.1.0]heptan-2-ols. This azaspirocyclic ring skeleton can also be obtained in one pot from the tert-butyldimethylsilyl- protected N-tosyl-N-(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols and diethylzinc/diiodomethane.

Facile synthesis of azaspirocycles via iron trichloride-promoted cyclization/chlorination of cyclic 8-Aryl-5-aza-5-tosyl-2-en-7-yn-1-ols

A simple and efficient FeCl3-promoted cyclization/chlorination of cyclic tosylamine-tethered 8-aryl-2-en-7-yn-1-ols was observed. The reaction proceeded instantaneously at 23 °C in air to afford (Z)-4- (arylchloromethylene)-substituted azaspiro

Trifluoromethanesulfonic acid-catalyzed tandem semi-pinacol rearrangement/alkyne-aldehyde metathesis reaction of arylpropagylsulfonamide- tethered 2,3-epoxycyclohexan-1-ols to spiropiperidines

A simple and efficient trifluoromethanesulfonic acid-catalyzed cycloisomerization of arylpropagylsulfonamide-tethered 2,3-epoxycyclohexan-1-ols is described. The cyclization proceeds via tandem semi-pinacol rearrangement/alkyne-aldehyde metathesis to affo

Palladium-Catalyzed Preparation of Carbon and Oxygen Spirocycles

A variety of substituted spiroundecene and spirodecene systems have been prepared by utilizing ?-allylpalladium chemistry in the key ring-forming step.