587829-57-0

Basic information

• Product Name: Cyclobutanecarbonitrile, 1-[[(1S)-1-phenylethyl]amino]-
• CAS NO: 587829-57-0
• Molecular Formula: C13H16N2
• Molecular Weight: 200.283
• Mol File: 587829-57-0.mol

Chemical Properties

• CAS DataBase Reference: Cyclobutanecarbonitrile, 1-[[(1S)-1-phenylethyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanecarbonitrile, 1-[[(1S)-1-phenylethyl]amino]-(587829-57-0)
• EPA Substance Registry System: Cyclobutanecarbonitrile, 1-[[(1S)-1-phenylethyl]amino]-(587829-57-0)

Safety Data

• Hazardous Substances Data: 587829-57-0(Hazardous Substances Data)

Upstream product

• 1191-95-3 cyclobutanone 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 143-33-9 sodium cyanide 

Downstream Products

• 587829-70-7 (1'S)-1-[(1'-methylbenzyl)amino]cyclobutanecarboxamide 

Relevant articles and documents

First synthesis of (1S,2S)- and (1R,2R)-1-amino-2-isopropylcyclobutanecarboxylic acids by asymmetric Strecker reaction from 2-substituted cyclobutanones

An efficient and easy one-pot reaction from readily available racemic 2-substituted cyclobutanones gave, by means of asymmetric Strecker synthesis in the presence of an amine chiral auxiliary, two major aminonitriles with excellent diastereoselectivity. After separation, the major cis-aminonitriles were hydrolysed and hydrogenolysed to lead for the first time to pure non-racemic (+)-1-amino-2-isopropylcyclobutanecarboxylic acid (ACBC) and its antipode.