587829-72-9

Upstream product

• 587829-68-3 (1S,2S,1'S)-1-[(1'-methylbenzyl)amino]-2-iso-propylcyclobutanecarbonitrile 
• 27608-63-5 (+/-)-2-isopropylcyclobutanone 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 587829-75-2 (1S,2S)-1-amino-2-isopropylcyclobutanecarboxamide 

Relevant academic research and scientific papers

First synthesis of (1S,2S)- and (1R,2R)-1-amino-2-isopropylcyclobutanecarboxylic acids by asymmetric Strecker reaction from 2-substituted cyclobutanones

An efficient and easy one-pot reaction from readily available racemic 2-substituted cyclobutanones gave, by means of asymmetric Strecker synthesis in the presence of an amine chiral auxiliary, two major aminonitriles with excellent diastereoselectivity. After separation, the major cis-aminonitriles were hydrolysed and hydrogenolysed to lead for the first time to pure non-racemic (+)-1-amino-2-isopropylcyclobutanecarboxylic acid (ACBC) and its antipode.