58785-73-2Relevant academic research and scientific papers
Enzymatic resolution of α-methyleneparaconic acids and evaluation of their biological activity
Chakrabarty, Kuheli,Defrenza, Ivana,Denora, Nunzio,Drioli, Sara,Forzato, Cristina,Franco, Massimo,Lentini, Giovanni,Nitti, Patrizia,Pitacco, Giuliana
, p. 239 - 246 (2015)
Both enantiomers of three biologically relevant paraconic acids-MB-3, methylenolactocin, and C75-were obtained with enantioselectivities up to 99% by kinetic enzymatic resolutions. Good enantiomeric excesses were obtained for MB-3 and methylenolactocin, using α-chymotrypsin and aminoacylase as enantiocomplementary enzymes, while C75 was resolved with aminoacylase. They all were evaluated for their antiproliferative, antibacterial, and antifungal activities, showing weak effects and practically no difference between enantiomers in each case. At high concentrations (16-64μg/mL), (-)- C75 acted as an antimicrobial agent against Gram-positive bacteria.
Synthesis of both enantiomers of methylenolactocin, nephrosterinic acid and protolichesterinic acid via tandem aldol-lactonization reactions
Kongsaeree, Palangpon,Meepowpan, Puttinan,Thebtaranonth, Yodhathai
, p. 1913 - 1922 (2007/10/03)
Both forms of the enantiomerically pure methylenolactocin, nephrosterinic and protolichesterinic acid have been synthesized via tandem aldol-lactonization reactions from corresponding optically active itaconate-anthracene adducts.
