587870-57-3Relevant academic research and scientific papers
Synthesis and antioxidant activity of hydroxylated phenanthrenes as cis-restricted resveratrol analogues
Ding, De-Jun,Cao, Xiao-Yan,Dai, Fang,Li, Xiu-Zhuang,Liu, Guo-Yun,Lin, Dong,Fu, Xing,Jin, Xiao-Ling,Zhou, Bo
, p. 1011 - 1019 (2012)
Five hydroxylated phenanthrenes as "cis-configuration-fixed" resveratrol analogues differing in the number and position of the hydroxyl groups were designed and synthesized. Their antioxidant activity was studied by ferric reducing antioxidant power, 2,2-diphenyl-1-picrylhydrazyl free radical-scavenging, and DNA strand breakage-inhibiting assays, corresponding to their electron-donating, hydrogen-transfer and DNA-protecting abilities, respectively. In the above assays, their activity depends significantly on the number and position of the hydroxyl groups, and most of them are more effective than resveratrol. Noticeably, compound 9b (2,4,6-trihydroxyl phenanthrene) with the same hydroxyl group substitutions as resveratrol, is superior to the reference compound, highlighting the importance of extension of the conjugation over multiple aromatic-rings. Similar activity sequences were obtained in different experimental models, but the appreciable differences could contribute detailed insights into antioxidant mechanisms. Based on these results, the hydroxylated phenanthrenes may be considered as a novel type of resveratrol-directed antioxidants.
Palladium/Norbornene-Catalyzed Indenone Synthesis from Simple Aryl Iodides: Concise Syntheses of Pauciflorol F and Acredinone A
Liu, Feipeng,Dong, Zhe,Wang, Jianchun,Dong, Guangbin
supporting information, p. 2144 - 2148 (2019/01/24)
To show the synthetic utility of palladium/norbornene (Pd/NBE) cooperative catalysis, here we report concise syntheses of indenone-based natural products, pauciflorol F and acredinone A, which are enabled by direct annulation between aryl iodides and unsa
