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1-(4-chloro-2-methylphenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, also known as LY-294002, is a pyrazolopyrimidine derivative that functions as a potent and selective inhibitor of phosphatidylinositol 3-kinase (PI3K). This enzyme plays a crucial role in cellular processes such as growth, proliferation, and survival. LY-294002 is widely utilized in research to understand the role of PI3K in diseases like cancer, diabetes, and cardiovascular diseases and is also explored as a potential therapeutic agent for these conditions. However, its potent inhibitory activity may lead to off-target effects, necessitating caution in its application.

58791-64-3

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58791-64-3 Usage

Uses

Used in Pharmaceutical Research:
LY-294002 is used as a research chemical for studying the role of PI3K in various disease processes. Its application is based on its ability to inhibit PI3K, providing insights into the enzyme's contribution to diseases such as cancer, diabetes, and cardiovascular diseases.
Used in Cancer Research:
In cancer research, LY-294002 is used as a PI3K inhibitor to investigate the enzyme's involvement in tumor growth and progression. 1-(4-chloro-2-methylphenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine helps researchers understand the signaling pathways that contribute to cancer development and identify potential therapeutic targets.
Used in Drug Development:
LY-294002 is also used in the development of therapeutic agents for the treatment of diseases where PI3K plays a significant role. Its potent inhibitory activity against PI3K makes it a candidate for further development into a drug that could potentially treat conditions like cancer, diabetes, and cardiovascular diseases, although the potential for off-target effects must be carefully considered and mitigated.
Used in Cell Signaling Studies:
In cell biology, LY-294002 serves as a tool to study the impact of PI3K inhibition on cellular signaling pathways. This helps researchers to elucidate the complex interactions within the cell and the role of PI3K in these processes.
Used in the Development of Combination Therapies:
Given its role in inhibiting PI3K, LY-294002 may also be used in the development of combination therapies, where it could potentially enhance the efficacy of other treatments by targeting specific cellular pathways involved in disease progression.
Used in Diagnostic Applications:
In diagnostics, LY-294002 could be employed to identify the presence or activity of PI3K in patient samples, which may be indicative of certain disease states or responses to treatment.
Used in the Biotech Industry:
In the biotech sector, LY-294002 may be utilized in the creation of genetically modified organisms or cell lines that are engineered to overexpress or suppress PI3K, aiding in the study of its role in various biological processes and disease mechanisms.

Check Digit Verification of cas no

The CAS Registry Mumber 58791-64-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,7,9 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 58791-64:
(7*5)+(6*8)+(5*7)+(4*9)+(3*1)+(2*6)+(1*4)=173
173 % 10 = 3
So 58791-64-3 is a valid CAS Registry Number.

58791-64-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-chloro-2-methylphenyl)-3-methylpyrazolo[3,4-d]pyrimidine-4,6-diamine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:58791-64-3 SDS

58791-64-3Upstream product

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