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Usage

Uses

Used in Pharmaceutical Research and Development:
5-AMINO-1-(2,4-DICHLOROPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE is utilized as a building block in the synthesis of new drug candidates due to its unique chemical structure and biological activity. Its presence of a cyano group, amino group, and chlorophenyl substituents may contribute to the development of compounds with specific therapeutic effects.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-AMINO-1-(2,4-DICHLOROPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE is employed for its potential to contribute to the discovery of new therapeutic agents. Its structural features suggest that it may be relevant for the design of molecules with targeted biological interactions, which could be beneficial in treating various diseases and conditions.
Note: Since the provided materials do not specify particular applications or industries for 5-AMINO-1-(2,4-DICHLOROPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE, the uses listed are general and based on the compound's potential in pharmaceutical and medicinal chemistry. Further research would be required to identify specific applications and industries where 5-AMINO-1-(2,4-DICHLOROPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE could be effectively utilized.

Upstream product

• 63917-11-3 (ethoxyethylidene)malononitrile 
• 5446-18-4 2,4-dichlorophenyl hydrazine hydrochloride 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 101309-64-2 5-Amino-1-(2,4-dichloro-phenyl)-3-methyl-1H-pyrazole-4-carbothioic acid amide 

Relevant academic research and scientific papers

Pyrazolyl-tetrazoles and imidazolyl-pyrazoles as potential anticoagulants and their integrated multiplex analysis virtual screening

This article reports a novel virtual screening algorithm seeking the rational identification of novel lead anticoagulants. Seven 5-(3-methyl-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles and seven novel 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-3-methyl-1H-pyrazole

Synthesis and activity of novel tetrazole compounds and their pyrazole-4-carbonitrile precursors against Leishmania spp

A new series of 5-(1-aryl-3-methyl-1H-pyrazol-4-yl)-1H-tetrazole derivatives (4a-m) and their precursor 1-aryl-3-methyl-1H-pyrazole-4- carbonitriles (3a-m) were synthesized and evaluated as antileishmanials against Leishmania braziliensis and Leishmania amazonensis promastigotes in vitro. In parallel, the cytotoxicity of these compounds was evaluated on the RAW 264.7 cell line. The results showed that among the assayed compounds the substituted 3-chlorophenyl (4a) (IC50/24 h = 15 ± 0.14 μM) and 3,4-dichlorophenyl tetrazoles (4d) (IC50/24 h = 26 ± 0.09 μM) were the most potent against L. braziliensis promastigotes, as compared the reference drug pentamidine, which presented IC50 = 13 ± 0.04 μM. In addition, 4a and 4d derivatives were less cytotoxic than pentamidine. However, these tetrazole derivatives (4) and pyrazole-4- carbonitriles precursors (3) differ against each of the tested species and were more effective against L.braziliensis than on L. amazonensis.