58804-70-9Relevant academic research and scientific papers
Iron-mediated one-pot formal nitrocyclization onto unactivated alkenes
Taniguchi, Tsuyoshi,Fujii, Tatsuya,Ishibashi, Hiroyuki
supporting information; experimental part, p. 653 - 655 (2011/03/22)
One-pot synthesis of heterocycles having a nitromethyl group was achieved by sequential steps that involved chloronitration of alkenes using iron(iii) nitrate nonahydrate followed by elimination and intramolecular Michael addition. This reaction provides
Base-catalyzed carbon-carbon bond formation reactions of ω-hydroxylactams
Speckamp, W. N.,Boer, J. J. J. de
, p. 410 - 414 (2007/10/02)
Active methylene compounds such as methyl ketones, 1,3-dicarbonyl systems and nitromethane condense under the influence of base with ω-hydroxylactams, thereby forming α-alkylated nitrogen heterocycles.The ease of alkylation is detemined by the position of a tautomeric equilibrium between ω-hydroxylactam and the open-chain amide-aldehyde, which is dependent upon the type of N-substituent and upon the lactam ring size.Some applications for the products obtained are indicated.
