58810-67-6Relevant academic research and scientific papers
Chemoenzymatic preparation of enantiopure isomers of 4-aminochroman-3-ol and 1-amino-1,2,3,4-tetrahydronaphthalen-2-ol
Recuero, Veronica,De Gonzalo, Gonzalo,Brieva, Rosario,Gotor, Vicente
, p. 4224 - 4230 (2007/10/03)
Enantiomerically pure N-protected cis-4-aminochroman-3-ol (key precursor in the synthesis of novel HIV second-generation protease inhibitors), its trans isomer and both cis- and trans-1-amino-1,2,3,4-tetrahydronaphthalen-2-ol, useful chiral catalysts in o
Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof
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Page/Page column 83, (2010/01/31)
γ-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.
Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains
Cheng, Yuan,Zhang, Fengqi,Rano, Thomas A,Lu, Zhijian,Schleif, William A,Gabryelski, Lori,Olsen, David B,Stahlhut, Mark,Rutkowski, Carrie A,Lin, Jiunn H,Jin, Lixia,Emini, Emilio A,Chapman, Kevin T,Tata, James R
, p. 2419 - 2422 (2007/10/03)
Indinavir analogues with blocked metabolism sites show highly improved pharmacokinetic profiles in animals. The cis-aminochromanol substituted analogues exhibited excellent potency against both the wild-type (NL4-3) virus and protease inhibitor-resistant HIV strains.
Stereoselective hydrogen bromide-promoted hydrogenation of an α-hydroxyoxime
Davies,Taylor,Marcoux,Matty,Wu,Hughes,Reider
, p. 8021 - 8025 (2007/10/03)
Hydrogen bromide has been demonstrated to provide optimal cis-selectivity in the reduction of 4-chromanone α-hydroxyoxime (25:1 cis/trans) in 94% yield. This reaction is pivotal in the synthesis of cis-aminochromanol. (C) 2000 Elsevier Science Ltd.
