58818-65-8Relevant academic research and scientific papers
Microwave enhanced Knoevenagel condensation of malonic acid on basic alumina
Kwon, Pan-Suk,Kim, Young-Mee,Kang, Chul-Joong,Kwon, Tae-Woo,Chung, Sung-Kee,Chang, Young-Tae
, p. 4091 - 4100 (1997)
An improved Knoevenagel condensation of malonic acid and aldehydes can be achieved by microwave irradiation over alumina. A number of diacids were prepared in good yields in very short reaction times.
Solvent-free bentonite-catalyzed condensation of malonic acid and aromatic aldehydes under microwave irradiation
Loupy, Andre,Song, Suk-Jin,Sohn, Sun-Mee,Lee, Young-Mee,Kwon, Tae-Woo
, p. 1220 - 1222 (2007/10/03)
Solvent-free condensation between malonic acid and aromatic aldehydes in the presence of bentonite was investigated. Various diacids were obtained in good to moderate yields and in very short short reaction times under microwave irradiation. The method showed simplicity in performance, non-aqueous work-up, no side products and low cost.
Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives
Neustadt,Smith,Nechuta,Bronnenkant,Haslanger,Watkins,Foster,Sybertz
, p. 2461 - 2476 (2007/10/02)
A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.
ENKEPHALINASE ENZYME INHIBITING COMPOUNDS
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, (2008/06/13)
Chiral 2-(2-benzyl-3-mercaptopropionylamino)-1-alkanol derivatives and chiral 2-(2-benzyl-3-mercaptopropionylamino)-4-methylthiobutyric acids are inhibitors of enkephalinase enzyme, reflecting their clinical utility as analgesics or anticonvulsant agents, or as therapy for disorders in which endogenous enkephalin levels are below normal.
