58821-98-0

Basic information

• Product Name: 12-DEOXYPHORBOL 13-PHENYLACETATE
• Synonyms: 12-deoxyphorbolphenylacetate;9a-phenylacetate;12-DEOXYPHORBOL 13-PHENYLACETATE;5H-Cyclopropa(3,4)benz(1,2-E)azulen-5-one, 1,1A-alpha,1B-beta,4,4A,7A-alpha,7B,8,9,9A-decahydro-4A-beta,7B-alpha,9A-alpha-trihydroxy-3-(hydroxymethyl)-1,1,6,8-alpha-tetramethyl-, 9A-phenylacetate;Benzeneacetic acid, (1ar,1bs,4ar,7as,7br,8R,9as)-1,1A,1B,4,4A,5,7A,7B,8,9-decahydro-4A,7B-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-E)azulen-9A-yl ester;Brn 1898359;Ccris 6293;12-Deoxyphorbol 13-Phenylacetate >99%
• CAS NO: 58821-98-0
• Molecular Formula: C₂₈H₃₄O₆
• Molecular Weight: 466.57
• Mol File: 58821-98-0.mol

Chemical Properties

• Boiling Point: 529.38°C (rough estimate)
• Flash Point: 209.1°C
• Appearance: /
• Density: 1.0905 (rough estimate)
• Vapor Pressure: 6.48E-17mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• PKA: 11.36±0.70(Predicted)
• CAS DataBase Reference: 12-DEOXYPHORBOL 13-PHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 12-DEOXYPHORBOL 13-PHENYLACETATE(58821-98-0)
• EPA Substance Registry System: 12-DEOXYPHORBOL 13-PHENYLACETATE(58821-98-0)

Safety Data

• Hazardous Substances Data: 58821-98-0(Hazardous Substances Data)

Usage

Synthetic chemical compound

12-deoxyphorbol 13-phenylacetate is a synthetic chemical compound that is derived from the diterpene phorbol.

Potential anti-tumor properties

Studies have shown that 12-deoxyphorbol 13-phenylacetate can inhibit the growth of various cancer cell lines, making it a promising compound for cancer treatment.

Ability to induce cell differentiation

12-deoxyphorbol 13-phenylacetate is known for its ability to induce the differentiation of cells.

Anti-inflammatory effects

12-deoxyphorbol 13-phenylacetate has been found to have anti-inflammatory effects, which could make it useful in the treatment of inflammatory conditions.

Ongoing research

Research on 12-deoxyphorbol 13-phenylacetate continues to explore its potential therapeutic applications and mechanisms of action.
It's worth noting that while 12-deoxyphorbol 13-phenylacetate has shown promise in preclinical studies, it's important to conduct further research to fully understand its potential benefits and risks before it can be used in clinical practice.

InChI:InChI=1/C28H34O6/c1-16-10-21-26(32,24(16)31)14-19(15-29)11-20-23-25(3,4)27(23,13-17(2)28(20,21)33)34-22(30)12-18-8-6-5-7-9-18/h5-11,17,20-21,23,29,32-33H,12-15H2,1-4H3/t17-,20+,21-,23?,26-,27+,28-/m1/s1

Upstream product

• 1173884-74-6 C₂₀-O-trityl-prostratin 
• 60857-08-1 prostratin 
• 1262389-74-1 C₂₀-O-trityl-prostratin-ol 
• 1035455-45-8 C₂₈H₃₄N₂O₆ 

Relevant articles and documents

DITERPENOID COMPOUNDS THAT ACT ON PROTEIN KINASE C (PKC)

This present disclosure relates to protein kinase C (PKC) modulating compounds, methods of treating a subject with cancer using the compounds, and combination treatments with a second therapeutic agent.

Process to Produce Prostratin and Structural or Functional Analogs Thereof

This invention concerns a process to convert a hydroxyl group (bold in R3C—OH) in a tigliane-type compound to a hydrogen (bold in R3C—H) to obtain deoxytigliane-type compounds or structural or functional analogs thereof. The process has wide application particularly to produce specific biologically active compounds in quantity for use as pharmaceuticals. In particular the process can be used to convert phorbol to a 12-deoxytigliane (prostrating which is a therapeutic lead for the treatment of AIDS. New compositions of matter are also disclosed.