58825-94-8

Basic information

• Product Name: TRANS-N-P-TOLYLSULFONYL-1,2-DIAMINOCYCLOHEXANE
• Synonyms: N-[(1S,2S)-2-aminocyclohexyl]-4-methylbenzenesulfonamide
• CAS NO: 58825-94-8
• Molecular Formula: C13H20N2O2S
• Molecular Weight: 268.38
• Mol File: 58825-94-8.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 417.447°C at 760 mmHg
• Flash Point: 206.265°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: TRANS-N-P-TOLYLSULFONYL-1,2-DIAMINOCYCLOHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-N-P-TOLYLSULFONYL-1,2-DIAMINOCYCLOHEXANE(58825-94-8)
• EPA Substance Registry System: TRANS-N-P-TOLYLSULFONYL-1,2-DIAMINOCYCLOHEXANE(58825-94-8)

Safety Data

• Hazardous Substances Data: 58825-94-8(Hazardous Substances Data)

Usage

General Description

TRANS-N-P-TOLYLSULFONYL-1,2-DIAMINOCYCLOHEXANE is a chemical compound that belongs to the class of sulfonamides. It is commonly used as a reagent in organic synthesis for the preparation of various compounds. TRANS-N-P-TOLYLSULFONYL-1,2-DIAMINOCYCLOHEXANE has a cyclohexane ring with two amino groups and a tolylsulfonyl group in the trans position. It is often utilized as a chiral ligand in catalytic asymmetric synthesis reactions. This chemical is known for its role in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and properties make it a valuable building block in organic chemistry. Additionally, it is important to handle this compound with care as it may pose hazards if not used properly.

InChI:InChI=1/C13H20N2O2S/c1-10-6-8-11(9-7-10)18(16,17)15-13-5-3-2-4-12(13)14/h6-9,12-13,15H,2-5,14H2,1H3/t12-,13-/m1/s1

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 32044-22-7 (R,R)-1,2-diammoniumcyclohexane mono-(+)-tartrate salt 
• 1436-59-5 cis-cyclohexane-1,2-diamine 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 863016-86-8 (2R)-2-(N-toluene-4-sulfonyl)amino-1-cyclohexanone 
• 245085-44-3 (1R,2R)-trans-2-(N-toluene-4-sulfonyl)amino-1-cyclohexanol 
• 931-15-7 (1R,2R)-2-aminocyclohexanol 
• 882409-31-6 (2S,7aR)-2-phenyl-1-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-benzoimidazole 
• 882409-32-7 (1R,2S)-cis-(N-2-benzylamino-cyclohexyl)-toluenesulfonamide 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 694-83-7 rac-diaminocyclohexane 
• 32044-22-7 (R,R)-1,2-diaminocyclohexane*(+)-tartric acid 
• 21436-03-3 (S,S)-1,2-diaminocyclohexane 
• 1257216-14-0 C₂₀H₂₄N₂O₄S 

Downstream Products

• 1360897-77-3 4-methyl-N-((1R,2R)-2-(2-((4-methyl cyclohexa-1,4-dienyl)methoxy)ethylamino)cyclohexyl)benzenesulfonamide hydrochloride 
• 1384518-62-0 (S,S,S,S)-N,N'-bis(2-(p-toluenesulfonylamino)cyclohexyl)trimethylenediamine 
• 1384518-61-9 (S, S, S, S)-N, N'-bis(2-(p-toluenesulfonylamino)cyclohexyl)ethylenediamine 
• 174182-33-3 [(1R,2R)-2-(Toluene-4-sulfonylamino)-cyclohexyl]-carbamic acid tert-butyl ester 
• 143585-47-1 (R,R)-1,2-bis(tosylamino)cyclohexane 

Relevant articles and documents

A modular approach to trans-chelating, N-heterocyclic carbene ligand complexes

The N-methyl bis-imidazolium salts 3 were converted to the silver carbenes 7, then reacted to give palladium(II) complexes 4 with trans-chelating, bidentate bis-imidazolylidine ligands. The similar salts 8, that do not have N-methyl substituents, gave the

A four-hydrogenated 1, 8 - naphthyridine apperception composition preparation method and its prepared chiral products

The invention discloses a preparation method of a tetrahydro 1, 8-naphthyridine compound. The preparation method comprises the following steps: under the existence of a chiral catalyst, enabling a compound with the structure shown in the formula (1) (in the description) and hydrogen to be subjected to addition reaction, wherein the chiral catalyst is a coordination compound with the structure shown in the formula (2) (in the description). The invention further provides a chiral product of the tetrahydro 1, 8-naphthyridine compound, prepared through the preparation method. According to the invention, the proper compound with the structure shown in the formula (1) (in the description) is used as a substrate, and the proper coordination compound with the structure shown in the formula (2) (in the description) is used as the chiral catalyst to perform selective hydrogenation reduction on 1, 8-naphthyridine compound with the structure shown in the formula (1) by adopting hydrogen, so that the chiral product of the tetrahydro 1, 8-naphthyridine compound is prepared with low cost. The chiral product of the tetrahydro 1, 8-naphthyridine compound can be used as a biologically active compound and a structural building block of a chiral drug.

A four-hydrogenated 1, 5 - naphthyridine apperception composition preparation method and its prepared chiral products

The invention discloses a method for preparing a tetrahydro-1,5-naphthyridine compound. The method comprises the following steps: carrying out an addition reaction between a compound with the structure shown as a formula (1) and hydrogen in the presence of a chiral catalyst, wherein the chiral catalyst is a coordination complex with a structure shown as a formula (2). The invention also provides a chiral product of the tetrahydro-1,5-naphthyridine compound prepared by the method. The proper compound with the structure shown as the formula (1) is selected as a substrate, the proper coordination complex with the structure shown as the formula (2) is selected as the chiral catalyst, and selective hydrogenation reduction of the 1,5-naphthyridine compound with the structure shown as the formula (1) is realized by adopting hydrogen, so that the chiral product of the tetrahydro-1,5-naphthyridine compound is prepared at low cost. The chiral product of the tetrahydro-1,5-naphthyridine compound prepared by the invention can serve as a structure block of bioactive compounds and chiral drugs.