58845-56-0

Upstream product

• 1188368-36-6 Nα-tert-butyloxycarbonyl-β-(N6-benzyloxycarbonyl)-adenin-1-yl-alanine 
• 84856-32-6 (S)-2-Amino-3-(5-amino-6-chloro-pyrimidin-4-ylamino)-propionic acid 
• 84894-26-8 (S)-2-Amino-3-(6-chloro-purin-9-yl)-propionic acid; hydrochloride 

Downstream Products

• 74757-90-7 L-β-(adenylyl-N⁹)alanyl-N^ε-Z-L-lysine methyl ester bistrifluoracetate 
• 74757-88-3 N^α-tert-butyloxycarbonyl-L-β-(adeninyl-N⁹)-α-alanyl-N^ε-benzyloxycarbonyl-L-lysine methyl ester 
• 113845-48-0 N-Boc-L-tyrosyl-glycyl-glycyl-L-β-(adeninyl-N⁹)-α-alanine methyl ester 
• 113845-51-5 N-Boc-L-tyrosyl-D-alanyl-glycl-L-β-(adeninyl-N⁹)-α-alanine methyl ester 

Relevant academic research and scientific papers

Purine alanine derivative used for tumor therapy, and preparation method and application of derivative

The invention discloses a purine alanine derivative used for tumor therapy, and a preparation method and an application of the derivative, and belongs to the technical field of synthesis of antitumor medicines. The purine alanine derivative used for tumor

SYNTHESIS OF OPTICALLY ACTIVE 9-PURINYL-α-AMINO ACIDS

A general method for the synthesis of optically active 9-purinyl-α-amino acids by condensation of 5-amino-4,6-dichloropyrimidine with α,ω-diamino carboxylic acids and subsequent cyclization of the Nω-(5-amino-4-chloro-6-pyrimidinyl)-amino acids with triethyl orthoformate was developed.A number of 6-substituted α-amino-ω-(9-purinyl)carboxylic acids were obtained by nucleophilic substitution of the chlorine atom in the α-amino-ω-(6-chloro-9-purinyl)carboxylic acids.