58861-66-8

Upstream product

• 36916-45-7 2-Benzyl-4-methoxycarbonylthiazole 
• 36916-44-6 2-benzyl-1,3-thiazole-4-carboxylic acid 
• 136209-74-0 4-Dimethylamino-6-phenyl-3,4-dihydro-2H-[1,4]thiazine-3-carboxylic acid methyl ester 

Downstream Products

• 70126-97-5 2-phenylcarbamoyl-thiazole-4-carboxylic acid methyl ester 
• 1370731-49-9 methyl 2-benzoyl-5-phenylthiazole-4-carboxylate 
• 1315510-34-9 dimethyl 2,2'-dibenzoyl-bis-5,5'-thiazole-4,4'-dicarboxylate 
• 70126-91-9 2-((E)-hydroxyimino-phenyl-methyl)-thiazole-4-carboxylic acid methyl ester 
• 70126-92-0 2-((Z)-hydroxyimino-phenyl-methyl)-thiazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Pd(ii)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage

The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance. The Royal Society of Chemistry 2012.

FORMATION DE 2H-1,4-THIAZINES, 2-BENZYLTHIAZOLES ET 2-BENZOYLTHIAZOLES PAR ACTION DE LA SILICE SUR LES 4-AMINO-3,4-DIHYDRO-2H-1,4-THIAZINES

In the presence of silica, 4-dimethylamino-3,4-dihydro-2H-1,4-thiazines 1 afford 2H-1,4-thiazines 2 with good yields, 2-benzyl-4-methoxycarbonylthiazoles 3 or 2-aroyl-4-methoxycarbonylthiazoles 4 depending on substituents bound to the thiazinic cycle and experimental conditions.As for 2H-1,4-thiazines 2, they give rise to bisthiazines by a duplication reaction. Key words: 2-(Dialkylhydrazono)thioacetophenones; 3,4-dihydro-2H-1,4-thiazines; 2H-1,4-thiazines; 2-benzyl-4-methoxycarbonylthiazoles; 2-aroyl-4-methoxycarbonylthiazoles.