58861-78-2

Basic information

• Product Name: 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester(9CI)
• Synonyms: 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester(9CI)
• CAS NO: 58861-78-2
• Molecular Formula: C5H7NO2S
• Molecular Weight: 145.18
• Product Categories: CARBOXYLICESTER
• Mol File: 58861-78-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 228.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 2.22±0.40(Predicted)
• CAS DataBase Reference: 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester(9CI)(58861-78-2)
• EPA Substance Registry System: 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester(9CI)(58861-78-2)

Safety Data

• Hazardous Substances Data: 58861-78-2(Hazardous Substances Data)

Upstream product

• 52-89-1 l-cysteine hydrochloride 
• 79-22-1 methyl chloroformate 
• 119072-55-8 tert-butylisonitrile 
• 44641-43-2 cysteine methyl ester 

Relevant articles and documents

LITHIATION OF Δ2-THIAZOLINES: THE C2-ANION APPROACH TO 2-SUBSTITUTED DERIVATIVES AND THEIR REACTIVITY

Lithiation of 2-unsubstituted Δ2-thiazolines and quenching with various electrophiles to 2-functionalized derivatives is reported.In particular quenching of thiazolines (1a and 1b) with trimethylsilyl chloride affords the corresponding 2-trimethylsilyl-Δ2-thiazolines (7a and 7b).The reactivity of these masked C2-anions toward electrophiles is described.Similar approach is developped for chiral 4--2-thiazoline (12).The synthesis of the chiral 2-formyl derivative, generated in situ from the C2-anion and N-formylmorpholine, and its reactivity toward phosphonium salt are also discussed.