588698-74-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 4968-68-7 3-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one 
• 10299-44-2 8-azaadenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant academic research and scientific papers

Cyclic dinucleotide compound, preparation method and application thereof

The invention discloses a cyclic dinucleotide compound, a preparation method and an application thereof, specifically, the invention relates to a compound of a formula (I), a pharmaceutically acceptable salt thereof, the preparation method thereof, and the application in the preparation of a medicine for treatment and/or prevention of a disease associated with activation of STING protein or as a vaccine adjuvant. The diseases associated with activation of the STING protein include viral infections, bacterial infections, cancers, diseases related to the immune system, and the like.

Substrate analogues for an RNA-editing adenosine deaminase: Mechanistic investigation and inhibitor design

ADARs are adenosine deaminases that act on RNA and are responsible for RNA-editing reactions that occur in eukaryotic mRNAs, including the mRNAs of glutamate and serotonin receptors. ADARs capable of editing biologically relevant RNA substrates have been