588701-97-7Relevant academic research and scientific papers
N-Hydroxy and N-acyloxy peptides: Synthesis and chemical modifications
Lawrence, James,Cointeaux, Laure,Maire, Pascal,Vallee, Yannick,Blandin, Veronique
, p. 3125 - 3141 (2008/03/12)
The preparation of a series of N-hydroxy peptides is described, along with their acylation on the oxygen of the pseudopeptide bond. Nineteen N-acyloxy peptides, first examples of this new class of pseudopeptides, were thus synthesized; they present a range of acyl groups, including N-protected amino acyl groups. Possibilities of elongation for these pseudopeptides were also investigated. The Royal Society of Chemistry 2006.
Straightforward synthesis of N-hydroxy peptides
Maire, Pascal,Blandin, Véronique,Lopez, Monique,Vallée, Yannick
, p. 671 - 674 (2007/10/03)
N-Hydroxy dipeptides are readily synthesized by reduction of the corresponding oximes. The two diastereomers obtained are easily separated by flash chromatography. They can be coupled with a third amino acid moiety - without protection of the hydroxyl group - to give N-hydroxy tripeptides.
