588708-44-5Relevant academic research and scientific papers
The scope of catalytic enantioselective tandem carbonyl ylide formation - Intramolecular [3 + 2] cycloadditions
Hodgson, David M.,Labande, Agnes H.,Pierard, Francoise Y. T. M.,Exposito Castro, Maria A.
, p. 6153 - 6159 (2007/10/03)
Catalytic enantioselective tandem carbonyl ylide formation-intramolecular 1,3-dipolar cycloaddition reactions of 2-diazo-3,6-diketoesters show promising scope in terms of asymmetric induction as the tethered alkene/alkyne dipolarophile component is varied. Cycloadditions were found to occur in moderate to very good yields, with a difference in ee exhibited by the electronically different 2-diazo-3,6-diketoesters 1, 25 and 33, 34. Values for ee of up to 90% for alkene dipolarophiles and up to 86% for alkyne dipolarophiles were obtained.
