58888-93-0Relevant academic research and scientific papers
ω-Dialkylalkanoic acid derivatives used to induce antianoxic activity
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, (2008/06/13)
ω-Dialkylalkanoic acid derivatives of the formula: STR1 in which R1 and R2, which can be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms and n represents 0, 1, 2 or 3. They possess a competitive inhibitory activity with respect to γ-aminobutyric α-ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders, whether resulting or not from cerebral ischemia, and disorders relating to the field of neuropsychiatry.
Research in dipropylacetic series. XII. Aliphatic ramified acids and alcohols with anticonvulsant activity
Taillandier,Benoit Guyod,Boucherle,et al.
, p. 453 - 462 (2007/10/05)
Previous results obtained about 2 propyl pentanoic acid (dipropylacetic or DPA) have been extended to other dialkylalkanoic acids having less than 14 carbon atoms and to some of their precursors (alcohols) or derivatives (amides). The effect of lengthening the chain bonding between the carbon bearing the two alkyl chains and the functional carbon on about 50 molecules is discussed. The anticonvulsant activity's length and strength often increases when lengthening that chain.
