58899-27-7 Usage
Uses
Used in Pharmaceutical Industry:
Aripiprazole Metabolite is used as an active pharmaceutical ingredient (API) for the development of antipsychotic medications. It is particularly useful in the treatment of schizophrenia, bipolar disorder, and other related psychiatric conditions. The metabolite contributes to the overall efficacy of Aripiprazole by modulating dopamine receptor activity, which helps in managing the symptoms of these disorders.
Used in Research and Development:
Aripiprazole Metabolite is used as a research compound for studying the pharmacological properties and mechanisms of action of Aripiprazole. It is valuable in understanding the metabolic pathways and the role of metabolites in the overall therapeutic effects of the drug. This knowledge can be applied to optimize drug formulations, improve drug delivery systems, and develop new therapeutic strategies for the treatment of psychiatric disorders.
Used in Quality Control and Analytical Testing:
Aripiprazole Metabolite is used as a reference standard in the quality control and analytical testing of Aripiprazole-containing pharmaceutical products. It helps in the identification, quantification, and quality assessment of the drug and its metabolites in various pharmaceutical formulations, ensuring the safety, efficacy, and consistency of the final product.
Used in Drug Metabolism Studies:
Aripiprazole Metabolite is used in drug metabolism studies to investigate the metabolic pathways and enzyme interactions involved in the biotransformation of Aripiprazole. This information is crucial for understanding the pharmacokinetics, pharmacodynamics, and potential drug-drug interactions of Aripiprazole, which can help in the development of personalized treatment strategies and the optimization of drug dosages for individual patients.
Check Digit Verification of cas no
The CAS Registry Mumber 58899-27-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,8,9 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 58899-27:
(7*5)+(6*8)+(5*8)+(4*9)+(3*9)+(2*2)+(1*7)=197
197 % 10 = 7
So 58899-27-7 is a valid CAS Registry Number.
58899-27-7Relevant academic research and scientific papers
Liu, Zhifang,Li, Zuojie,Du, Tao,Chen, Yan,Wang, Qingpeng,Li, Guoshuai,Liu, Min,Zhang, Ning,Li, Dacheng,Han, Jun
, p. 362 - 375 (2021)
The design of novel platinum(iv) complexes with mitochondria injury competence, besides the DNA damage mechanism, is a promising way to develop new platinum drugs. Herein, dihydro-2-quinolone (DHQLO) as a mitocan was incorporated into the platinum(iv) system for the first time to prepare a new series of DHQLO platinum(iv) compounds. Complex 1b could effectively inhibit the proliferation of tumor cells in vitro and in vivo. It accumulated at higher levels in both whole cells and DNA, and easily underwent intercellular reduction to release platinum(ii) and DHQLO moieties. The released platinum(ii) complex caused serious DNA damage by covalent conjunction with the DNA duplex, and remarkably increased the expression of the γ-H2AX protein. Moreover, 1b also caused serious mitochondria injury to induce mitochondrial membrane depolarization and increase ROS generation. Such actions upon DNA and mitochondria activate the p53 apoptotic pathway synergetically in tumor cells by upregulating the protein p53 and apoptotic proteins caspase9 and caspase3, which efficiently promoted the apoptotic death of tumor cells. Compound 1b with such synergic mechanism exhibited great potential in reversing cisplatin resistance and improving antitumor efficacies.
