58910-28-4

Usage

Uses

Used in Organic Chemistry:
Ethyl (1-ethoxyethylidene)carbazate is used as a reagent in chemical reactions and synthesis processes for the formation of hydrazones and as a building block for the preparation of various functionalized compounds.
Used in Pharmaceutical Research and Drug Development:
Ethyl (1-ethoxyethylidene)carbazate is used as a valuable intermediate in the synthesis of diverse organic molecules with potential applications in medicinal and industrial settings due to its versatile chemical reactivity and potential to form a wide range of derivatives with various biological activities.

InChI:InChI=1/C7H14N2O3/c1-4-11-6(3)8-9-7(10)12-5-2/h4-5H2,1-3H3,(H,9,10)

Upstream product

• 1000-84-6 O-ethyl acetimidate 
• 4114-31-2 ethylhydrazine carboxylate 
• 2208-07-3 ethyl acetimidate hydrochloride 

Downstream Products

• 182929-48-2 (3,5-Dimethyl-[1,2,4]triazol-4-yl)-carbamic acid ethyl ester 
• 860612-51-7 4-(4-bromophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1313389-78-4 4-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1269125-43-0 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1426434-68-5 5-methyl-4-(4-benzoylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1428154-56-6 4-(4-methylbenzoate)-5-methyl-3,4-dihydro-2H-1,2,4-triazol-3-one 
• 860612-43-7 2,4-dihydro-4-[4-(tert-butyl)phenyl]-5-methyl-3H-1,2,4-triazol-3-one 

Relevant academic research and scientific papers

Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties

Carbonic anhydrase enzymes (EC 4.2.1.1, CAs) are metalloenzyme families that catalyze the rapid conversion of H2O and CO2 to HCO3 – and H+. CAs are found in different tissues where they participate in various significant biochemical processes such as ion transport, carbon dioxide respiration, ureagenesis, lipogenesis, bone resorption, electrolyte secretion, acid-base balance, and gluconeogenesis. In such processes, many CAs are significant therapeutic targets because of their inhibitory potentials especially in the treatment of some diseases such as edema, glaucoma, obesity, cancer, epilepsy, and osteoporosis. Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are also valuable compounds for different therapeutic applications including Alzheimer's disease. In this work, we report a fast and effective synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and also their CA and cholinesterases inhibitory properties. Our findings showed that these Schiff base derivatives, with triazole ring, found as strong CA and cholinesterases inhibitors.

Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities

By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy work-up and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. N'-{[4-Amino-3-(2-bromobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide and N'-{[4-amino-3-(3,4-dichlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide had a good effect on lipase inhibition.