58910-37-5

Upstream product

• 109-01-3 1-methyl-piperazine 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 70-34-8 2,4-Dinitrofluorobenzene 
• 89-02-1 2,4-dinitrobenzenesulfonic acid 

Relevant academic research and scientific papers

Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

Synthesis of o-Nitroarylamines via Ipso Nucleophilic Substitution of Sulfonic Acids

A mild, efficient, and eco-friendly method for the synthesis of o-nitroarylamine from o-nitroaryl sulfonic acid via ipso nucleophilic aryl substitution by amine is described. The products have been obtained with good yields at room temperature without the assistance of any metal, activating agent, or toxic oxidant. This method is useful for racemization-free synthesis of N-aryl amino acid esters.

DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE

One subject of the invention is a meia-phenylenediamine compound having formula (I) below, the addition salts thereof with an acid and the solvates thereof: in which: ? R represents a hydrogen or halogen atom; a C1-C4 alkyl group; a carboxyl group or a (C1-C4)alkoxycarbonyl group, ? R1 represents a C1-C10(hydroxy)alkyl group, optionally interrupted with one or more non-adjacent oxygen atoms or non-adjacent NR' substituents, substituted by a cationic CAT group, ? R2 represents a hydrogen atom or a C1-C4(hydroxy)alkyl group, ? R1 and R2 may form, together with the atom that bears them, a cationic heterocycle with 5 to 8 members, ? R' represents a hydrogen atom or a C1-C4(hydroxy)alkyl group; ? An represents an anion or a mixture of anions which are organic or inorganic and cosmetically acceptable.

IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.

Structural studies of some 1-polymethyleneimino-2,4-dinitrobenzenes and related compounds; Crystal structure of 1-(cis-2′,6′-dimethylpiperidin-l′-yl)-2,4-dinitrobenzene

The ultraviolet and 1H n.m.r. spectra of some 1-polymethyleneimino-2,4-dinitrobenzenes and related compounds are discussed. The effect of trifluoroacetic acid on these spectra was also investigated; with 1-azetidiny 1-2,4-dinitrobenzene, acid-c