58939-46-1

Basic information

• Product Name: 1-aminocyclopropanol
• Synonyms: 1-Aminocyclopropanol; cyclopropanol, 1-amino-
• CAS NO: 58939-46-1
• Molecular Formula: C₃H₇NO*ClH
• Molecular Weight: 73.0938
• Mol File: 58939-46-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 125.2°C at 760 mmHg
• Flash Point: 29.5°C
• Density: 1.299g/cm³
• Vapor Pressure: 5.74mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 1-aminocyclopropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-aminocyclopropanol(58939-46-1)
• EPA Substance Registry System: 1-aminocyclopropanol(58939-46-1)

Safety Data

• Hazardous Substances Data: 58939-46-1(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Structure

Cyclic aminoalcohol

Common use

Reagent in organic synthesis

Role

Key intermediate in the synthesis of various pharmaceuticals and bioactive compounds

Physical state at room temperature

Colorless liquid

Solubility

Highly soluble in water

Known for

Precursor in the production of cyclic amines

Industrial and pharmaceutical applications

Various

Biological activities

Potential antiviral and anticancer agent

Versatility

Important applications in chemistry, pharmaceuticals, and potentially in medicine

Upstream product

• 86750-52-9 1-(Toluol-4-sulfonyl)-cyclopropylamin-hydrochlorid 
• 41879-50-9 1-ethoxycyclopropylisocyanate 
• 16223-79-3 1-Acetoxycyclopropanol 
• 42501-57-5 bis(1-hydroxycyclopropyl)-amine 
• 63805-77-6 1-Isocyano-1-(toluol-4-sulfonyl)-cyclopropan 
• 86750-51-8 1-Formylamino-1-(toluol-4-sulfonyl)-cyclopropan 
• 41879-49-6 tert-butyl N-(1-ethoxycyclopropyl)carbamate 

Downstream Products

• 63805-78-7 N-(1-hydroxycyclopropyl)-benzamide 
• 86750-54-1 N-(1-Hydroxy-cyclopropyl)-4-methyl-benzenesulfonamide 
• 86750-55-2 4-Chloro-N-(1-hydroxy-cyclopropyl)-benzamide 
• 86750-56-3 Cyclopropanecarboxylic acid (1-hydroxy-cyclopropyl)-amide 
• 86750-57-4 2,2-Bis-(4-chloro-phenyl)-N-(1-hydroxy-cyclopropyl)-acetamide 

Relevant articles and documents

A New Synthesis of Coprine and O-Ethylcoprine

Coprine (1), a toxine of the mushroom Coprinus atramentarius, was synthesized starting from the 2-amino- and 1-carboxy-protected L-glutamic acids 4 and 12.Compound 4 was first decarboxylated by radical chain reaction to bromide 5 which underwent ring closure to cyclopropanecarboxylate 6 on treatment with NaH (Scheme 1).Subsequent oxidative electrolysis of 7 to form tert-butyl N-(1-ethoxycyclopropyl)carbamate (8) and acidic hydrolysis yielded the 1-aminocyclopropanol hydrochloride (9).Selective cleavage of the amino-protecting group of 8(-> 10 or 11), coupling of the corresponding amine 13 with L-glutamic acid 12, and acidic hydrolysis of the resulting L-glutamine derivative 17 yielded O-ethylcoprine (3) and coprine (1).

Substituted cyclopropyl benzamides and pharmaceutical preparations and methods of use employing such compounds

Compounds of the formula, wherein R1 is a hydrogen atom, a methyl group or an ethyl group and R2 is a hydrogen atom, wherein n is 1 or 2, provided that R1 is a methyl or an ethyl group when R2 is a hydrogen atom; methods for the preparation thereof; inter