58969-47-4Relevant academic research and scientific papers
Isolation, Structure Elucidation, Semi-Synthesis, and Structural Modification of C19-Diterpenoid Alkaloids fromAconitum apetalumand Their Neuroprotective Activities
Wan, Lin-Xi,Zhang, Ji-Fa,Zhen, Yong-Qi,Zhang, Lan,Li, Xiaohuan,Gao, Feng,Zhou, Xian-Li
, p. 1067 - 1077 (2021)
Five new aconitine-type C19-diterpenoid alkaloids, apetalrines A-E (1-5), were isolated fromAconitum apetalum. Their structures were determined by analysis of 1D and 2D NMR, IR, and HRESIMS data. Semisynthesis of apetalrine B (2) from its parent compound aconorine was achieved to confirm the structure proposed. Twenty derivatives of2(11a-11l12a12b12d12e12j12k12m12n) were synthesized via a unified approach relying on simple coupling reactions. The evaluation of neuroprotective effects of compounds (1-511b11c11f-11i12a12b12d12e12k12m12n) with low cytotoxicity revealed compound2to exhibit good neuroprotective effects in H2O2-treated SH-SY5Y cells at a concentration of 50 μM. A series of studies using flow cytometry, staining, and Western blotting on2indicated that its neuroprotective effects may arise from inhibiting cell apoptosis.
