58971-89-4Relevant academic research and scientific papers
Room-Temperature Alkynylation of Phosphine Oxides with Copper Acetylides: Practical Synthesis of Alkynylphosphine Oxides
Gérard, Phidéline,Veillard, Romain,Alayrac, Carole,Gaumont, Annie-Claude,Evano, Gwilherm
, p. 633 - 638 (2017/01/18)
An efficient procedure for the synthesis of alkynylphosphine oxides based on the oxidative alkynylation of secondary phosphine oxides with copper acetylides was developed. Activation with molecular oxygen in the presence of either a mixture of 1,2-dimethylimidazole and triethylamine or N-methylimidazole alone enabled the formal umpolung of the poorly nucleophilic copper acetylides, which were coupled with phosphine oxides under remarkably mild conditions. Notable features of this procedure are the availability of the starting materials, its user-friendliness, and its mild conditions, which allow the synthesis of complex alkynylphosphine oxides.
Preparations of N- and P-substituted acetylenes under metal-free conditions
Chen, Hong,Zheng, Qingjuan,Dong, Wanrong,Peng, Zhihong,An, Delie
supporting information, p. 1438 - 1445 (2016/09/14)
An efficient strategy towards triazole- or phosphine-oxide-substituted alkynes with the assistance of strong base LiHMDS is described. The facile and practical reaction took place from easily prepared substrates in a one-pot manner without participation of any transition metal catalysts or ligands, exhibiting good functional groups tolerance (up to 37 examples) and high efficiency (up to 90% yields). The isolation of the key intermediate proved the hypothesis of the proposed mechanism of the one-pot preparation.
Cs2CO3-promoted one-pot synthesis of alkynylphosphonates, -phosphinates, and -phosphine oxides
Wang, Yulei,Gan, Jiepeng,Liu, Liu Leo,Yuan, Hang,Gao, Yuxing,Liu, Yan,Zhao, Yufen
, p. 3678 - 3683 (2014/05/06)
A novel and efficient Cs2CO3-promoted phosphorylation or phosphinylation of various 1,1-dibromo-1-alkenes with readily available trialkyl phosphites, ethyl diphenylphosphinite, or diethyl phenylphosphonite has been developed under metal-free conditions, providing a practical and powerful tool for one-pot synthesis of valuable alkynylphosphonates, -phosphinates, and -phosphine oxides in good to excellent yields.
