58977-08-5Relevant articles and documents
Chemistry of Quinones. Part 7. Synthesis of Anthracyclinone Analogues via Diels-Alder Reactions of 1,4-Anthraquinones
Gupta, Dharmendra N.,Hodge, Philip,Khan, Naeem
, p. 689 - 696 (2007/10/02)
Diels-Alder adducts were formed by reaction of 1,4-anthraquinone with buta-1,3-diene, with 1-acetoxy-, 1-methyl-, 2-methyl-, and 2,3-dimethyl-buta-1,3-diene, and with cyclohexa-1,3-diene.Adducts were also prepared by reaction of 9-chloro-10-hydroxy-1,4-anthraquinone with buta-1,3-diene and with 2-methylbuta-1,3-diene.Some of the linear tetracyclic adducts were transformed to 1,2,3,4-tetrahydro-1,5,12-trihydroxynaphthacene-6,11-quinone (21) and 2-acetyl-1,2,3,4-tetrahydro-2,5,12-trihydroxynaphthacene-6,11-quinone (7).The latter has been converted by other workers into 4-demethoxydaunomycinone (48) and 4-demethoxydaunomycin (8).
A short, efficient synthesis of an anthracycline antitumor antibiotic synthon
Alexander,Mitscher
, p. 3403 - 3406 (2007/10/13)
-
Daunomycinone analogues via the Diels Alder reaction. Synthesis and chemistry of some 6,11 dihydroxy 5,12 naphthacenediones
Lee,Martinez,Smith,Henry
, p. 2296 - 2303 (2007/10/05)
-