590-92-1

Basic information

• Product Name: Propanoicacid, 3-bromo-
• Synonyms: Propionicacid, 3-bromo- (6CI,7CI,8CI);Propionic acid, b-bromo- (2CI);2-Carboxyethyl bromide;3-Bromopropanoic acid;3-Bromopropionic acid;NSC 2638;beta-Bromopropanoicacid
• CAS NO: 590-92-1
• Molecular Formula: C₃H₅BrO₂
• Molecular Weight: 151.9672
• EINECS: 209-694-1
• Product Categories: Aromatic Propionic Acids;Organic acids;Pyridines derivates;omega-Bromocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;C1 to C5;Carbonyl Compounds;Carboxylic Acids
• Mol File: 590-92-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 57-63℃
• Boiling Point: 239.5 °C at 760 mmHg
• Flash Point: 98.7 °C
• Appearance: white to pale yellow or orange crystal
• Density: 1.781 g/cm³
• Vapor Pressure: 0.0134mmHg at 25°C
• Refractive Index: 1.4753 (estimate)
• Storage Temp.: 2-8°C
• Solubility: H2O: 0.1?g/mL, clear
• PKA: 4.00(at 25℃)
• Water Solubility: 0.1 g/mL
• Merck: 14,1433
• BRN: 1071333
• CAS DataBase Reference: Propanoicacid, 3-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoicacid, 3-bromo-(590-92-1)
• EPA Substance Registry System: Propanoicacid, 3-bromo-(590-92-1)

Safety Data

• Hazard Codes: F:Flammable;;
• Statements: R11:; R34:
• Safety Statements: S26:; S36/37/39:; S45:
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: UE7875000
• TSCA: Yes
• HazardClass: 4.1
• PackingGroup: III
• Hazardous Substances Data: 590-92-1(Hazardous Substances Data)

Usage

Chemical Properties

white to pale yellow or orange crystalline. soluble in water, alcohol, ether, chloroform, benzene. Hydrolysis in alkaline solution generates hydroxypropionic acid. Corrosive. for organic synthesis.

Uses

3-Bromopropionic acid used as quaternization agent in amperometric biosensors.

Application

3-Bromopropionic acid is a widely used chemical intermediate. It can be used as a starting material to synthesize derivatives such as esters, acid halides and amides; the active group bromine can undergo a series of reactions, and is mainly used in the fields of pesticides and medicines. Such as the pesticides diflufenacil, furalax and so on.

Preparation

3-Bromopropionic acid is prepared by reacting acrylonitrile with hydrogen bromide to obtain bromopropionitrile and then hydrolyzing it. Add acrylonitrile to boiling hydrobromic acid, reflux at 130°C for 6 hours, extract the solid obtained by filtration with ethanol, and obtain the crude product after recovering ethanol by distillation under reduced pressure. By heating 2-cyanoethanol and 40% hydrobromic acid to reflux for 2h, 3-bromopropionic acid can also be produced with a yield of over 80%.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 2807, 1949 DOI: 10.1021/ja01176a061Organic Syntheses, Coll. Vol. 1, p. 131, 1941

Safety Profile

Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.

Purification Methods

The acid crystallises as plates from CCl4. It is soluble in organic solvents and H2O. Its methyl ester has b 65o/18mm and 80o/27mm. The S-benzylisothiouronium salt has m 136o. [Kendall & McKenzie Org Synth Coll Vol I 131 1941, Beilstein 2 IV 764.]

InChI:InChI=1/C3H5BrO2/c4-2-1-3(5)6/h1-2H2,(H,5,6)/p-1

Synthetic route

bromopropionitrile (2417-90-5) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With benzene-1,2-dicarboxylic acid for 0.75h; microwave irradiation;	95%
With hydrogen bromide

tert-butyl 3-bromopropionate (55666-43-8) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With KSF clay In acetonitrile for 4h; Heating;	89%

3-Hydroxypropionitrile (109-78-4) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With hydrogen bromide In water for 4h; Reflux;	82%
With hydrogen bromide
With hydrogen bromide

2-Bromopropionic acid (598-72-1) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With tetrabutyl phosphonium bromide at 160℃; under 760.051 Torr; for 20h;	79%
With tetrabutyl phosphonium bromide In melt at 160℃; under 760.051 Torr; for 20h;

1-bromo-3-propanol (627-18-9) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With jones reagent at 0℃;	75%
With tert.-butylnitrite; N-hydroxyphthalimide; oxygen In acetonitrile at 80℃; for 48h; Schlenk technique;	20%
With nitric acid

propionic acid (802294-64-0) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With hydrogenchloride; oxygen; potassium bromide; sodium nitrite In chloroform; water at 40℃; for 18h; Sealed tube; Irradiation; Schlenk technique;	68%

propionic acid (802294-64-0) → 3-Bromopropionic acid (590-92-1) + chloropropionic acid (107-94-8) + 2-Bromopropionic acid (598-72-1) + (R,S)-2-chloropropionic acid (598-78-7)

Conditions	Yield
With hydrogenchloride; oxygen; potassium bromide; sodium nitrite In chloroform; water at 40℃; under 760.051 Torr; for 18h; Sealed tube; Irradiation;	A 65% B n/a C 23% D n/a

n-butyl magnesium bromide (693-03-8) + β-Propiolactone (57-57-8) → 3-Bromopropionic acid (590-92-1) + oenanthic acid (111-14-8)

Conditions	Yield
With copper(I) bromide In diethyl ether at -5℃; for 1h;	A 60% B 30%
With copper(I) bromide In tetrahydrofuran at -5℃; for 1h;	A 40% B 44%

β-Propiolactone (57-57-8) + 4-(tert-butyldiphenylsilyloxy)-1-butyne (88158-68-3) → 3-Bromopropionic acid (590-92-1) + 7-(tert-butyldiphenylsilyloxy)hept-4-ynoic acid (104329-69-3)

Conditions	Yield
With n-butyllithium; dimethylaluminum chloride In toluene at -35℃; for 3h; Inert atmosphere;	A 15% B 38%

4-pentynoic acid (6089-09-4) + (2-bromoethoxy)(tert-butyl)diphenylsilane (139897-19-1) → 3-Bromopropionic acid (590-92-1) + 7-(tert-butyldiphenylsilyloxy)hept-4-ynoic acid (104329-69-3)

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium at -35℃; Inert atmosphere;	A 15% B 29%

β-Propiolactone (57-57-8) + phenylmagnesium bromide → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With diethyl ether at -6 - 0℃;

β-Propiolactone (57-57-8) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With water; sodium bromide at 25℃;
With water; hydrogen bromide

3-iodopropanoic acid (141-76-4) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With bromine

3-bromopropanal (65032-54-4) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With nitric acid

carbon tetrabromide (558-13-4) + propionic acid (802294-64-0) → 3-Bromopropionic acid (590-92-1) + 2-Bromopropionic acid (598-72-1)

Conditions	Yield
at 150 - 180℃;
at 150 - 180℃;

acrylic acid (79-10-7) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With hydrogen bromide at 100℃;
With hydrogen bromide at 12℃;

3-hydroxypropionic acid (503-66-2) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With hydrogen bromide

3-amino propanoic acid (107-95-9) → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With nitrosyl bromide
With hydrogen bromide; nitrosyl bromide at 25℃;

3,12-bis(3'-bromo-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dichloride (86641-76-1) → 3-Bromopropionic acid (590-92-1) + chloropropionic acid (107-94-8) + 3,12-bis(3'-chloro-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dibromide (121051-82-9) + 3,12-Bisacrylyl-3,12-diaza-6,9-diazoniadispiro<5,2,5,2>hexadecane dichloride (95461-34-0) + 3,12-bis(3'-hydroxy-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dichloride (122842-21-1) + 3-hydroxypropionic acid (503-66-2)

Conditions	Yield
In water at 70℃; for 5h; Product distribution; Kinetics; Rate constant; various time; other temperature;

4'-nitrophenyl 3-bromopropionate (78939-58-9) → 3-Bromopropionic acid (590-92-1) + p-nitrophenolate (14609-74-6)

Conditions	Yield
With hydroxide; sodium chloride at 27℃; Product distribution; other p-nitrophenyl esters, dependence of the rate constant on the Taft polar substituent constant, correlation of the reactivity of N-acetyl-L-cysteine and of hydroxide, solvent isotope effect;
With hydroxide; sodium chloride at 37℃; Rate constant; Kinetics; Thermodynamic data; Ea, ΔH(ex), ΔS(ex);

3-Bromo-propionic acid 1-(2-isothiocyanato-ethoxy)-ethyl ester (140156-02-1) → 3-Bromopropionic acid (590-92-1) + 1-bromo-3-aza-4-oxo-5-thiaoctanoic acid (140156-06-5)

Conditions	Yield
With water at 20℃; for 4h;

hydrogen bromide (10035-10-6, 12258-64-9) + 3-Hydroxypropionitrile (109-78-4) → 3-Bromopropionic acid (590-92-1)

hydrogen bromide (10035-10-6, 12258-64-9) + 3-amino propanoic acid (107-95-9) + nitrosyl bromide → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
bei Zimmertemperatur;

β-Propiolactone (57-57-8) + magnesium bromide dietherate → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With diethyl ether

silver succinate → 3-Bromopropionic acid (590-92-1)

Conditions	Yield
With tetrachloromethane; bromine

bromopropionitrile (2417-90-5) + hydrogen bromide (10035-10-6, 12258-64-9) → 3-Bromopropionic acid (590-92-1)

3-iodopropanoic acid (141-76-4) + bromine water → 3-Bromopropionic acid (590-92-1)

1-bromo-3-chloropropyl acetate + nitric acid (7697-37-2) → 3-Bromopropionic acid (590-92-1) + chloropropionic acid (107-94-8)

acetic acid-(1-chloro-allyl ester) (10517-70-1) + hydrogen bromide (10035-10-6, 12258-64-9) → 3-Bromopropionic acid (590-92-1) + 3-chloro-propionic acid (?)

Conditions	Yield
folgenden Oxydieren mit konz. HNO3;

3-Bromopropionic acid (590-92-1) → 3-Bromopropionyl chloride (15486-96-1)

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 16h;	100%
With thionyl chloride for 8h; Inert atmosphere; Reflux;	80%
With thionyl chloride for 1h; Heating;	71%

3-Bromopropionic acid (590-92-1) + 2-Mercaptobenzothiazole (149-30-4) → 3-(benzothiazol-2-ylthio)propionic acid (4767-00-4)

Conditions	Yield
Stage #1: 2-Mercaptobenzothiazole With potassium carbonate In tetrahydrofuran for 0.166667h; Inert atmosphere; Stage #2: 3-Bromopropionic acid In tetrahydrofuran at 20℃; Inert atmosphere;	100%
With potassium hydroxide In ethanol for 3h; Heating;	83%

3-Bromopropionic acid (590-92-1) + 3-phenoxyaniline (3586-12-7) → 3-phenoxyaniline-3'-bromopropionamide (620597-96-8)

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;	100%
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 0.5h;

3-Bromopropionic acid (590-92-1) → 3-azidopropanoic acid (18523-47-2)

Conditions	Yield
With sodium azide In water	100%
With sodium azide In acetonitrile at 85℃; for 5h;	90%
With sodium azide In N,N-dimethyl-formamide for 4h; Reflux;	89%

3-Bromopropionic acid (590-92-1) + endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide (21715-90-2) → N-hydroxy-5-norbornene-2,3-dicarboximide bromopropanoate (872054-83-6)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide	99%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h;

3-Bromopropionic acid (590-92-1) → 3-bromopropionic anhydride (112489-79-9)

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; Glovebox;	99%

3-Bromopropionic acid (590-92-1) + para-bromobenzenethiol (106-53-6) → 3-(4-Bromophenylsulfanyl)propanoic Acid (13735-04-1)

Conditions	Yield
With sodium hydroxide; sodium carbonate In water	99%
With sodium hydroxide In water

3-Bromopropionic acid (590-92-1) + 6-fluoro-2-mercaptoquinazolin-4(3H)-one (69661-42-3) → 3-((6-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)thio)propanoic acid (1570174-61-6)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile at 20℃; for 16h;	99%

3-Bromopropionic acid (590-92-1) + 2-bromo-5-fluorobenzene-1-thiol (55389-14-5) → 3-[(2-bromo-5-fluorophenyl)sulfanyl]propionic acid

Conditions	Yield
Stage #1: 2-bromo-5-fluorobenzene-1-thiol With sodium hydroxide In water at 20℃; for 0.166667h; Stage #2: 3-Bromopropionic acid With potassium carbonate In water at 20℃; for 120h;	99%

3-Bromopropionic acid (590-92-1) + bis<2-(n-hexadecanoyloxycarbonyl)ethyl>amine (13080-33-6) → 3-bromopropionylbis<2-(n-hexadecanoyloxycarbonyl)ethyl>amine (82797-98-6)

Conditions	Yield
With dicyclohexyl-carbodiimide In chloroform for 1h; Ambient temperature;	98%

3-Bromopropionic acid (590-92-1) + 3-carboxy-2-mercaptopyridine (38521-46-9) → 3-(3-carboxy-2-pyridylthio)propionic acid (286472-02-4)

Conditions	Yield
With potassium hydroxide; sodium hydrogencarbonate at 60℃; for 4h; Substitution;	98%

3-Bromopropionic acid (590-92-1) + P(p-CH3OC6H4)3 (855-38-9) → C24H26O5P(1+)*Br(1-) (1394132-29-6)

Conditions	Yield
In toluene for 5h; Reflux;	98%

3-Bromopropionic acid (590-92-1) + (2S,3S)-3-((2-(2-chloro-5H-pyrrolo[2,3-b]pyrazin-7-yl)-5-fluoro-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octan-2-carboxylic acid ethyl ester → 3-(2-chloro-7-(4-(((2S,3S)-3-(ethoxycarbonyl)bicyclo[2.2.2]octan-2-yl)amino)-5-fluoro-6-(thiophen-2-yl)pyrimidin-2-yl)-5H-pyrrolo[2,3-b]pyrazin-5-yl)propionic acid

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	98%

3-Bromopropionic acid (590-92-1) + C35H48ClN3O10S → C38H52ClN3O12S

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	98%

3-Bromopropionic acid (590-92-1) + methyl D-lactate chlorosulfite → methyl (2S)-2-bromopropanoate (20047-41-0, 57885-43-5, 5445-17-0, 62076-23-7)

Conditions	Yield
With hydrogenchloride; hydrogen bromide In water	96.7%
With pyridine	95.6%

3-Bromopropionic acid (590-92-1) + 3-(benzyloxy)aniline (1484-26-0) → N-(3-(benzyloxy)phenyl)-3-bromopropanamide (620597-98-0)

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 0.5h;	96%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;	96%

3-Bromopropionic acid (590-92-1) + 4-amino-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester (1021498-06-5) → 4-(3-bromopropionylamino)-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester (1021498-15-6)

Conditions	Yield
Stage #1: 3-Bromopropionic acid With diisopropyl-carbodiimide In tetrahydrofuran for 0.5h; Stage #2: 4-amino-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester In tetrahydrofuran Inert atmosphere;	96%
Stage #1: 3-Bromopropionic acid With diisopropyl-carbodiimide In tetrahydrofuran for 0.5h; Stage #2: 4-amino-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester In tetrahydrofuran for 3h;	96%

3-Bromopropionic acid (590-92-1) + C9H15N2O3S(1-)*Na(1+) (952292-16-9) → C12H19N2O5S(1-)*Na(1+)

Conditions	Yield
at 140℃;	96%

3-Bromopropionic acid (590-92-1) + tert-butylisonitrile (119072-55-8, 7188-38-7) + phenylglyoxal hydrate (1074-12-0) + meso-1,2-diphenyl-1,2-diaminoethane (951-87-1, 5700-60-7, 16635-95-3, 29841-69-8, 35132-20-8, 107133-00-6) → (3R*,4S*,8aS*)-N-(tert-butyl)-6-oxo-1,3,4-triphenyl-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-8a-carboxamide

Conditions	Yield
Stage #1: phenylglyoxal hydrate; meso-1,2-diphenyl-1,2-diaminoethane In methanol at 20℃; for 0.166667h; Ugi Condensation; Stage #2: 3-Bromopropionic acid; tert-butylisonitrile In methanol for 24h; diastereoselective reaction;	96%

3-Bromopropionic acid (590-92-1) + Dioctadecylamine (112-99-2) → 3-bromopropionyldi-n-octadecyalmine (82797-99-7)

Conditions	Yield
With dicyclohexyl-carbodiimide In benzene for 3h; Ambient temperature;	95%

3-Bromopropionic acid (590-92-1) + 9-Propyl-2-phenylimidazo<1,2-a>benzimidazole (79349-48-7) → 13-Propyl-6,7-dihydro-5-oxobenzocyclohepten<5',6':4,5>imidazo<1,2-a>benzimidazole (86043-57-4)

Conditions	Yield
With PPA at 100 - 120℃; for 4h;	95%

3-Bromopropionic acid (590-92-1) + 9-Butyl-2-phenylimidazo<1,2-a>benzimidazole (79349-49-8) → 13-Butyl-6,7-dihydro-5-oxobenzocyclohepten<5',6':4,5>imidazo<1,2-a>benzimidazole (107486-38-4)

Conditions	Yield
With PPA at 100 - 120℃; for 4h;	95%

3-Bromopropionic acid (590-92-1) + 9-methyl-2-phenyl-9H-benzo[d]imidazo[1,2-a]imidazole (21431-82-3) → 13-Methyl-6,7-dihydro-5-oxobenzocyclohepten<5',6':4,5>imidazo<1,2-a>benzimidazole (86043-56-3)

Conditions	Yield
With PPA at 100 - 120℃; for 4h;	95%

3-Bromopropionic acid (590-92-1) + 9-Ethyl-2-phenylimidazo<1,2-a>benzimidazole (2208-82-4) → 13-Ethyl-6,7-dihydro-5-oxobenzocyclohepten<5',6':4,5>imidazo<1,2-a>benzimidazole (107486-37-3)

Conditions	Yield
With PPA at 100 - 120℃; for 4h;	95%

3-Bromopropionic acid (590-92-1) + 6,7-dimethyl-2-phenyl-9-ethylimidazo<1,2-a>benzimidazole (107486-31-7) → 10,11-Dimethyl-13-ethyl-6,7-dihydro-5-oxobenzocyclohepten<5',6':4,5>imidazo<1,2-a>benzimidazole (107486-39-5)

Conditions	Yield
With PPA at 100 - 120℃; for 4h;	95%

3-Bromopropionic acid (590-92-1) → 3-sulfopropanoic acid (44826-45-1)

Conditions	Yield
With sodium sulfite In water; acetone at 80℃; Inert atmosphere;	95%
With sodium sulfite In water at 110℃; for 12h; Strecker sulfite alkylation;

3-Bromopropionic acid (590-92-1) + 1-Decanol (112-30-1) → decyl bromopropionate (1255179-80-6)

Conditions	Yield
With toluene-4-sulfonic acid In para-xylene for 3h; Reflux;	95%
With zinc perchlorate; magnesium sulfate for 5h; Reflux;

3-Bromopropionic acid (590-92-1) + 1-dodecyl alcohol (112-53-8) → dodecyl bromopropionate (1098253-34-9)

Conditions	Yield
With toluene-4-sulfonic acid In para-xylene for 3h; Reflux;	95%
With zinc perchlorate; magnesium sulfate for 5h; Reflux;

3-Bromopropionic acid (590-92-1) + N-phenylhydrazinecarboselenoamide (14223-50-8) → 5-(2-bromoethyl)-N-phenyl-1,3,4-selenadiazol-2-amine

Conditions	Yield
With trichlorophosphate at 60 - 80℃; for 3h; Temperature; Reagent/catalyst;	95%
In trichlorophosphate at 50 - 80℃;

Upstream product

• 79-10-7 acrylic acid 
• 109-78-4 3-Hydroxypropionitrile 
• 503-66-2 3-hydroxypropionic acid 
• 627-18-9 1-bromo-3-propanol 
• 10035-10-6 hydrogen bromide 
• 107-95-9 3-amino propanoic acid 
• 598-72-1 2-Bromopropionic acid 
• 802294-64-0 propionic acid 
• 57-57-8 β-Propiolactone 
• 88158-68-3 4-(tert-butyldiphenylsilyloxy)-1-butyne 
• 6089-09-4 4-pentynoic acid 
• 139897-19-1 (2-bromoethoxy)(tert-butyl)diphenylsilane 
• 55666-43-8 tert-butyl 3-bromopropionate 
• 20986-22-5 (2-carboxyethyl)dimethylsulfonium bromide 

Downstream Products

• 130234-70-7 RM₄₈₅₇ 
• 5219-65-8 acide phenylthio-3 propanoique 
• 38584-58-6 N-(2-nitrophenyl)-β-alanine 
• 13739-35-0 3-[(4-methylphenyl)thio]propionic acid 
• 6310-27-6 3-[(4-chlorophenyl)sulfanyl]propanoic acid 
• 582-53-6 3-(2,4,5-trichloro-phenoxy)-propionic acid 
• 18241-98-0 N-(3-nitro-phenyl)-β-alanine 
• 114769-68-5 N-(4-sulfanilyl-phenyl)-β-alanine 
• 29636-75-7 3-bromo-1-phenylpropan-1-one 
• 5650-41-9 3-hydroxy-1-phenylpropan-1-one 
• 27850-43-7 3-bromopropionic acid phenyl ester 
• 123044-08-6 8-methyl-4-oxo-6-phenyl-2,3-dihydro-6H-pyrimido<2,3-b>thiazine-7-carboxylic acid ethyl ester 
• 16599-78-3 3-(phenylselanyl)propanoic acid 
• 4767-00-4 3-(benzothiazol-2-ylthio)propionic acid 

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The invention relates to a preparation method of an alkane brominated material. The preparation method comprises the following steps: adding alkane, a bromine-containing compound or elemental bromine,a catalyst and acid into a solvent; adding the solvent into a light-transmission reaction container under air or oxygen atmosphere; sealing; performing stirring reaction under constant pressure and light illumination conditions; then analyzing a nuclear magnetic yield, and performing extraction, drying, filtration, distillation under reduced pressure and column separation to obtain the alkane brominated material. Compared with the prior art, the preparation method disclosed by the invention has the advantages that by using low-cost and safe bromic salt as a bromine source, the air as an oxidizing agent and a nitrogen-containing reagent as the catalyst, reaction is carried out under the conditions of constant temperature and constant pressure, so that energy conservation and economy are realized, and the preparation method is convenient and safe to operate and is environmentally friendly.

METHODS OF MAKING ACRYLIC ACID FROM LACTIC ACID OR ITS DERIVATIVES IN LIQUID PHASE

Methods for making acrylic acid, acrylic acid derivatives, or mixtures thereof by contacting a feed stream containing lactic acid, lactic acid derivatives, or mixtures thereof with a molten salt catalyst comprising an ionic liquid (IL) and an acid in liquid phase are provided.