5900-42-5Relevant academic research and scientific papers
Novel Reaction of Uracil Derivatives Possessing Electron-withdrawing Groups at the 5-Position with Amines: Exchange Reaction between the N1-Portion of Uracils and Amines
Hirota, Kosaku,Kitade, Yukio,Sajiki, Hironao,Maki, Yoshifumi,Yogo, Motoi
, p. 367 - 373 (2007/10/02)
The reaction of 1,3-disubstituted uracils possessing an electron-withdrawing group such as nitro, carbamoyl, and cyano at 5-position with primary amines resulted in the exchange of the N1-portion of the uracil ring with the amine moiety.The exchange reactions were influenced by the nature of substituents at the 5- and N1-position.The reaction sequence is explained in terms of addition, ring-opening, and ring-closure.
Synthesis of 1-Substituted 5-Cyanouracils
Wolfbeis, Otto S.
, p. 182 - 185 (2007/10/02)
Condensation of (cyanoacetyl)urea (1) with aniline and trimethoxymethane affords (3-anilino-2-cyanoacryloyl)urea (2a), which thermally cyclizes to form strongly fluorescent 5-cyano-1-phenyluracil (3a).By using 2-aminopyridine or trimethoxymethane, other u
